An Lmx1b-miR135a2 Regulatory Circuit Modulates Wnt1/Wnt Signaling and Determines the Size of the Midbrain Dopaminergic Progenitor Pool

Angela Anderegg; Hsin-Pin Lin; Jun-An Chen; Giuliana Caronia-Brown; Natalya Cherepanova; Beth Yun; Milan Joksimovic; Jason Rock; Brian D. Harfe; Randy Johnson; Rajeshwar Awatramani

doi:10.1371/journal.pgen.1003973

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Peer-reviewed

Research Article

An Lmx1b-miR135a2 Regulatory Circuit Modulates Wnt1/Wnt Signaling and Determines the Size of the Midbrain Dopaminergic Progenitor Pool

Angela Anderegg,

Affiliation Northwestern University Feinberg School of Medicine, Department of Neurology and Center for Genetic Medicine, Chicago, Illinois, United States of America
⨯
Hsin-Pin Lin,

Affiliation Northwestern University Feinberg School of Medicine, Department of Neurology and Center for Genetic Medicine, Chicago, Illinois, United States of America
⨯
Jun-An Chen,

Affiliation Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
⨯
Giuliana Caronia-Brown,

Affiliation Northwestern University Feinberg School of Medicine, Department of Neurology and Center for Genetic Medicine, Chicago, Illinois, United States of America
⨯
Natalya Cherepanova,

Affiliation Northwestern University Feinberg School of Medicine, Department of Neurology and Center for Genetic Medicine, Chicago, Illinois, United States of America
⨯
Beth Yun,

Affiliation Northwestern University Feinberg School of Medicine, Department of Neurology and Center for Genetic Medicine, Chicago, Illinois, United States of America
⨯
Milan Joksimovic,

Affiliation Northwestern University Feinberg School of Medicine, Department of Neurology and Center for Genetic Medicine, Chicago, Illinois, United States of America
⨯
Jason Rock,

Affiliation Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America
⨯
Brian D. Harfe,

Affiliation Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America
⨯
Randy Johnson,

Affiliation Department of Biochemistry and Molecular Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Rajeshwar Awatramani

* E-mail: r-awatramani@northwestern.edu

Affiliation Northwestern University Feinberg School of Medicine, Department of Neurology and Center for Genetic Medicine, Chicago, Illinois, United States of America
⨯

An Lmx1b-miR135a2 Regulatory Circuit Modulates Wnt1/Wnt Signaling and Determines the Size of the Midbrain Dopaminergic Progenitor Pool

Angela Anderegg,
Hsin-Pin Lin,
Jun-An Chen,
Giuliana Caronia-Brown,
Natalya Cherepanova,
Beth Yun,
Milan Joksimovic,
Jason Rock,
Brian D. Harfe,
Randy Johnson

Published: December 12, 2013
https://doi.org/10.1371/journal.pgen.1003973

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Midbrain
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Neurons
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MicroRNAs
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Wnt signaling cascade
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In situ hybridization
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Gene expression
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Morphogens
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