Low Frequency Variants, Collapsed Based on Biological Knowledge, Uncover Complexity of Population Stratification in 1000 Genomes Project Data

Carrie B. Moore; John R. Wallace; Daniel J. Wolfe; Alex T. Frase; Sarah A. Pendergrass; Kenneth M. Weiss; Marylyn D. Ritchie

doi:10.1371/journal.pgen.1003959

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Research Article

Low Frequency Variants, Collapsed Based on Biological Knowledge, Uncover Complexity of Population Stratification in 1000 Genomes Project Data

Carrie B. Moore,

Affiliations Center for Human Genetic Research, Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America, Center for Systems Genomics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, Eberly College of Science, The Huck Institutes of the Life Sciences, University Park, Pennsylvania, United States of America
⨯
John R. Wallace,

Affiliation Center for Systems Genomics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, Eberly College of Science, The Huck Institutes of the Life Sciences, University Park, Pennsylvania, United States of America
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Daniel J. Wolfe,

Affiliation Center for Systems Genomics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, Eberly College of Science, The Huck Institutes of the Life Sciences, University Park, Pennsylvania, United States of America
⨯
Alex T. Frase,

Affiliation Center for Systems Genomics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, Eberly College of Science, The Huck Institutes of the Life Sciences, University Park, Pennsylvania, United States of America
⨯
Sarah A. Pendergrass,

Affiliation Center for Systems Genomics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, Eberly College of Science, The Huck Institutes of the Life Sciences, University Park, Pennsylvania, United States of America
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Kenneth M. Weiss,

Affiliation Department of Anthropology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
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Marylyn D. Ritchie

* E-mail: marylyn.ritchie@psu.edu

Affiliation Center for Systems Genomics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, Eberly College of Science, The Huck Institutes of the Life Sciences, University Park, Pennsylvania, United States of America
⨯

Low Frequency Variants, Collapsed Based on Biological Knowledge, Uncover Complexity of Population Stratification in 1000 Genomes Project Data

Carrie B. Moore,
John R. Wallace,
Daniel J. Wolfe,
Alex T. Frase,
Sarah A. Pendergrass,
Kenneth M. Weiss,
Marylyn D. Ritchie

Published: December 26, 2013
https://doi.org/10.1371/journal.pgen.1003959

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