Deletion of the Murine Cytochrome P450 Cyp2j Locus by Fused BAC-Mediated Recombination Identifies a Role for Cyp2j in the Pulmonary Vascular Response to Hypoxia

• Guo Ling Zhou ,

  Contributed equally to this work with: Guo Ling Zhou, Arkadi Beloiartsev

  Affiliation Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  ⨯
• Arkadi Beloiartsev ,

  Contributed equally to this work with: Guo Ling Zhou, Arkadi Beloiartsev

  Affiliation Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  ⨯
• Binglan Yu,

  Affiliation Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  ⨯
• David M. Baron,

  Affiliation Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  ⨯
• Weihua Zhou,

  Affiliation Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  ⨯
• Rasma Niedra,

  Affiliation Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  ⨯
• Naifang Lu,

  Affiliation Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  ⨯
• Laurel T. Tainsh,

  Affiliation Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  ⨯
• Warren M. Zapol,

  Affiliation Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  ⨯
• Brian Seed ,

  * E-mail: bseed@ccib.mgh.harvard.edu (BS); kdbloch@partners.org (KDB)

  ¶These senior authors also contributed equally to this work.

  Affiliation Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  ⨯
• Kenneth D. Bloch

  * E-mail: bseed@ccib.mgh.harvard.edu (BS); kdbloch@partners.org (KDB)

  ¶These senior authors also contributed equally to this work.

  Affiliations Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  ⨯