Recurrent Tissue-Specific mtDNA Mutations Are Common in Humans

• David C. Samuels ,

  Contributed equally to this work with: David C. Samuels, Chun Li

  Affiliation Center for Human Genetics Research, Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Chun Li ,

  Contributed equally to this work with: David C. Samuels, Chun Li

  Affiliation Center for Human Genetics Research, Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Bingshan Li,

  Affiliation Center for Human Genetics Research, Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Zhuo Song,

  Affiliation Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Eric Torstenson,

  Affiliation Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Hayley Boyd Clay,

  Affiliation Center for Human Genetics Research, Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Antonis Rokas,

  Affiliation Department of Biological Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Tricia A. Thornton-Wells,

  Affiliation Center for Human Genetics Research, Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Jason H. Moore,

  Affiliation Dartmouth Medical School, Department of Genetics, Computational Genetics Lab, Lebanon, New Hampshire, United States of America

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• Tia M. Hughes,

  Affiliation Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Robert D. Hoffman,

  Affiliation Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Jonathan L. Haines,

  Affiliation Center for Human Genetics Research, Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Deborah G. Murdock,

  Affiliation Center for Human Genetics Research, Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Douglas P. Mortlock,

  Affiliation Center for Human Genetics Research, Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Scott M. Williams

  * E-mail: scott.williams@dartmouth.edu

  Affiliations Center for Human Genetics Research, Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Dartmouth Medical School, Department of Genetics, Computational Genetics Lab, Lebanon, New Hampshire, United States of America

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