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Open Access
Peer-reviewed
Research Article
Mining the Human Phenome Using Allelic Scores That Index Biological Intermediates
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David M. Evans ,
Contributed equally to this work with: David M. Evans, Marie Jo A. Brion
* E-mail: dave.evans@bristol.ac.uk
Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom, University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia
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Marie Jo A. Brion ,
Contributed equally to this work with: David M. Evans, Marie Jo A. Brion
Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom, Broad Institute at MIT and Harvard, Cambridge, Massachusetts, United States of America, Queensland Brain Institute, University of Queensland, Brisbane, Australia
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Lavinia Paternoster,
Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
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John P. Kemp,
Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
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George McMahon,
Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
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Marcus Munafò,
Affiliation UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, University of Bristol, Bristol, United Kingdom
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John B. Whitfield,
Affiliation QIMR Berghofer Medical Research Institute, Brisbane, Australia
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Sarah E. Medland,
Affiliation QIMR Berghofer Medical Research Institute, Brisbane, Australia
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Grant W. Montgomery,
Affiliation QIMR Berghofer Medical Research Institute, Brisbane, Australia
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The GIANT consortium ,
¶Membership of the GIANT consortium, the CRP consortium, and the TAG Consortium is provided in the Supporting Information.
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The CRP consortium ,
¶Membership of the GIANT consortium, the CRP consortium, and the TAG Consortium is provided in the Supporting Information.
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The TAG Consortium ,
¶Membership of the GIANT consortium, the CRP consortium, and the TAG Consortium is provided in the Supporting Information.
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Nicholas J. Timpson,
Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
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Beate St. Pourcain,
Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
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Debbie A. Lawlor,
Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
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Nicholas G. Martin,
Affiliation QIMR Berghofer Medical Research Institute, Brisbane, Australia
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Abbas Dehghan,
Affiliation Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands
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Joel Hirschhorn,
Affiliations Broad Institute at MIT and Harvard, Cambridge, Massachusetts, United States of America, Division of Genetics and Endocrinology and Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts
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George Davey Smith
Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
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Mining the Human Phenome Using Allelic Scores That Index Biological Intermediates
- David M. Evans,
- Marie Jo A. Brion,
- Lavinia Paternoster,
- John P. Kemp,
- George McMahon,
- Marcus Munafò,
- John B. Whitfield,
- Sarah E. Medland,
- Grant W. Montgomery,
- The GIANT consortium
- Published: October 31, 2013
- https://doi.org/10.1371/journal.pgen.1003919