Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in Females

Serge McGraw; Christopher C. Oakes; Josée Martel; M. Cecilia Cirio; Pauline de Zeeuw; Winifred Mak; Christoph Plass; Marisa S. Bartolomei; J. Richard Chaillet; Jacquetta M. Trasler

doi:10.1371/journal.pgen.1003873

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Peer-reviewed

Research Article

Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in Females

Serge McGraw ,

Contributed equally to this work with: Serge McGraw, Christopher C. Oakes

Affiliation Departments of Pharmacology & Therapeutics, Pediatrics and Human Genetics, Research Institute at The Montreal Children's Hospital of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada
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Christopher C. Oakes ,

Contributed equally to this work with: Serge McGraw, Christopher C. Oakes

Affiliation Department of Epigenomics and Cancer Risk Factors, The German Cancer Research Center, Heidelberg, Baden-Württemberg, Germany
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Josée Martel,

Affiliation Departments of Pharmacology & Therapeutics, Pediatrics and Human Genetics, Research Institute at The Montreal Children's Hospital of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada
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M. Cecilia Cirio,

Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Pauline de Zeeuw,

Affiliation Departments of Pharmacology & Therapeutics, Pediatrics and Human Genetics, Research Institute at The Montreal Children's Hospital of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada
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Winifred Mak,

Affiliation Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
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Christoph Plass,

Affiliation Department of Epigenomics and Cancer Risk Factors, The German Cancer Research Center, Heidelberg, Baden-Württemberg, Germany
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Marisa S. Bartolomei,

Affiliation Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
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J. Richard Chaillet,

Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Jacquetta M. Trasler

* E-mail: Jacquetta.Trasler@mcgill.ca

Affiliation Departments of Pharmacology & Therapeutics, Pediatrics and Human Genetics, Research Institute at The Montreal Children's Hospital of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada
⨯

Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in Females

Serge McGraw,
Christopher C. Oakes,
Josée Martel,
M. Cecilia Cirio,
Pauline de Zeeuw,
Winifred Mak,
Christoph Plass,
Marisa S. Bartolomei,
J. Richard Chaillet,
Jacquetta M. Trasler

Published: November 21, 2013
https://doi.org/10.1371/journal.pgen.1003873

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DNA methylation
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Placenta
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X chromosome inactivation
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Blastocysts
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X chromosomes
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Genomic imprinting
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