Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage

Open Access

Peer-reviewed

Research Article

Scott R. Kennedy,

Affiliation Department of Pathology, University of Washington, Seattle, Washington, United States of America
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Jesse J. Salk,

Affiliations Department of Pathology, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America
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Michael W. Schmitt,

Affiliations Department of Pathology, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America
⨯
Lawrence A. Loeb

* E-mail: laloeb@u.washington.edu

Affiliations Department of Pathology, University of Washington, Seattle, Washington, United States of America, Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
⨯

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Point mutation
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Mitochondrial DNA
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Mitochondria
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Mutation
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Genomics
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Oxidative damage
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Nucleotide sequencing
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DNA damage
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