Type I-E CRISPR-Cas Systems Discriminate Target from Non-Target DNA through Base Pairing-Independent PAM Recognition

• Edze R. Westra ,

  Contributed equally to this work with: Edze R. Westra, Ekaterina Semenova

  * E-mail: westra.edze@gmail.com (ERW); severik@waksman.rutgers.edu (KS)

  Affiliation Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, Wageningen, The Netherlands

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• Ekaterina Semenova ,

  Contributed equally to this work with: Edze R. Westra, Ekaterina Semenova

  Affiliation Waksman Institute, Piscataway, New Jersey, United States of America

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• Kirill A. Datsenko,

  Affiliations Waksman Institute, Piscataway, New Jersey, United States of America, Purdue University, West Lafayette, Indiana, United States of America

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• Ryan N. Jackson,

  Affiliation Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America

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• Blake Wiedenheft,

  Affiliation Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America

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• Konstantin Severinov ,

  * E-mail: westra.edze@gmail.com (ERW); severik@waksman.rutgers.edu (KS)

  Affiliations Waksman Institute, Piscataway, New Jersey, United States of America, Department of Molecular Biology and Biochemistry, Rutgers, The State University, Piscataway, New Jersey, United States of America, Institutes of Molecular Genetics and Gene Biology, Russian Academy of Sciences, Moscow, Russia

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• Stan J. J. Brouns

  Affiliation Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, Wageningen, The Netherlands

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