Genome-Wide Association Mapping in Dogs Enables Identification of the Homeobox Gene, NKX2-8, as a Genetic Component of Neural Tube Defects in Humans

Noa Safra; Alexander G. Bassuk; Polly J. Ferguson; Miriam Aguilar; Rochelle L. Coulson; Nicholas Thomas; Peta L. Hitchens; Peter J. Dickinson; Karen M. Vernau; Zena T. Wolf; Danika L. Bannasch

doi:10.1371/journal.pgen.1003646

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Peer-reviewed

Research Article

Genome-Wide Association Mapping in Dogs Enables Identification of the Homeobox Gene, NKX2-8, as a Genetic Component of Neural Tube Defects in Humans

Noa Safra ,

* E-mail: nsafra@ucdavis.edu

Affiliation Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
⨯
Alexander G. Bassuk,

Affiliation Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America
⨯
Polly J. Ferguson,

Affiliation Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America
⨯
Miriam Aguilar,

Affiliation Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
⨯
Rochelle L. Coulson,

Affiliation Medical Microbiology and Immunology, Genome Center, MIND Institute, University of California Davis, Davis, California, United States of America
⨯
Nicholas Thomas,

Affiliation Department of Plant Pathology, University of California Davis, Davis, California, United States of America
⨯
Peta L. Hitchens,

Affiliation JD Wheat Veterinary Orthopedic Research Laboratory, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
⨯
Peter J. Dickinson,

Affiliation Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
⨯
Karen M. Vernau,

Affiliation Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
⨯
Zena T. Wolf,

Affiliation Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
⨯
Danika L. Bannasch

Affiliation Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
⨯

Genome-Wide Association Mapping in Dogs Enables Identification of the Homeobox Gene, NKX2-8, as a Genetic Component of Neural Tube Defects in Humans

Noa Safra,
Alexander G. Bassuk,
Polly J. Ferguson,
Miriam Aguilar,
Rochelle L. Coulson,
Nicholas Thomas,
Peta L. Hitchens,
Peter J. Dickinson,
Karen M. Vernau,
Zena T. Wolf

Published: July 18, 2013
https://doi.org/10.1371/journal.pgen.1003646

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Neural tube defects
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Frameshift mutation
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Dogs
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Spina bifida
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Genome-wide association studies
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Pets and companion animals
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Homeobox
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Single nucleotide polymorphisms
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