Histone Methyltransferase DOT1L Drives Recovery of Gene Expression after a Genotoxic Attack

Valentyn Oksenych; Alexander Zhovmer; Salim Ziani; Pierre-Olivier Mari; Jitka Eberova; Tiziana Nardo; Miria Stefanini; Giuseppina Giglia-Mari; Jean-Marc Egly; Frédéric Coin

doi:10.1371/journal.pgen.1003611

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Open Access

Peer-reviewed

Research Article

Histone Methyltransferase DOT1L Drives Recovery of Gene Expression after a Genotoxic Attack

Valentyn Oksenych ,

Contributed equally to this work with: Valentyn Oksenych, Alexander Zhovmer

Current address: Department of Genetics, Harvard Medical School, Children's Hospital, Immune Disease Institute, Howard Hughes Medical Institute, Boston, Massachusetts, United States of America.

Affiliation IGBMC, Department of Functional Genomics and Cancer, CNRS/INSERM/Université de Strasbourg, C. U. Strasbourg, France
⨯
Alexander Zhovmer ,

Contributed equally to this work with: Valentyn Oksenych, Alexander Zhovmer

Current address: Memorial Sloan-Kettering Cancer Center, The Rockefeller Research Laboratories, New York, New York, United States of America.

Affiliation IGBMC, Department of Functional Genomics and Cancer, CNRS/INSERM/Université de Strasbourg, C. U. Strasbourg, France
⨯
Salim Ziani,

Affiliation IGBMC, Department of Functional Genomics and Cancer, CNRS/INSERM/Université de Strasbourg, C. U. Strasbourg, France
⨯
Pierre-Olivier Mari,

Affiliation Université de Toulouse, UPS, IPBS, Toulouse, France
⨯
Jitka Eberova,

Affiliation IGBMC, Department of Functional Genomics and Cancer, CNRS/INSERM/Université de Strasbourg, C. U. Strasbourg, France
⨯
Tiziana Nardo,

Affiliation Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia, Italy
⨯
Miria Stefanini,

Affiliation Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia, Italy
⨯
Giuseppina Giglia-Mari,

Affiliation Université de Toulouse, UPS, IPBS, Toulouse, France
⨯
Jean-Marc Egly,

Affiliation IGBMC, Department of Functional Genomics and Cancer, CNRS/INSERM/Université de Strasbourg, C. U. Strasbourg, France
⨯
Frédéric Coin

* E-mail: fredr@igbmc.fr

Affiliation IGBMC, Department of Functional Genomics and Cancer, CNRS/INSERM/Université de Strasbourg, C. U. Strasbourg, France
⨯

Histone Methyltransferase DOT1L Drives Recovery of Gene Expression after a Genotoxic Attack

Valentyn Oksenych,
Alexander Zhovmer,
Salim Ziani,
Pierre-Olivier Mari,
Jitka Eberova,
Tiziana Nardo,
Miria Stefanini,
Giuseppina Giglia-Mari,
Jean-Marc Egly,
Frédéric Coin

Published: July 4, 2013
https://doi.org/10.1371/journal.pgen.1003611

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DNA transcription
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Chromatin
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Fluorescence recovery after photobleaching
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DNA repair
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Histones
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DNA damage
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DNA methylation
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