Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum Levels

• Gian Andri Thun,

  Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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• Medea Imboden ,

  Contributed equally to this work with: Medea Imboden, Ilaria Ferrarotti

  Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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• Ilaria Ferrarotti ,

  Contributed equally to this work with: Medea Imboden, Ilaria Ferrarotti

  Affiliation Center for Diagnosis of Inherited Alpha1-antitrypsin Deficiency, Institute for Respiratory Disease, IRCCS San Matteo Hospital Foundation, University of Pavia, Pavia, Italy

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• Ashish Kumar,

  Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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• Ma'en Obeidat,

  Affiliation James Hogg Research Centre, Institute for Heart and Lung Health, University of British Columbia, Vancouver, Canada

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• Michele Zorzetto,

  Affiliation Center for Diagnosis of Inherited Alpha1-antitrypsin Deficiency, Institute for Respiratory Disease, IRCCS San Matteo Hospital Foundation, University of Pavia, Pavia, Italy

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• Margot Haun,

  Affiliation Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria

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• Ivan Curjuric,

  Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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• Alexessander Couto Alves,

  Affiliation Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom

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• Victoria E. Jackson,

  Affiliation Departments of Health Sciences and Genetics, University of Leicester, Leicester, United Kingdom

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• Eva Albrecht,

  Affiliation Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany

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• Janina S. Ried,

  Affiliation Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany

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• Alexander Teumer,

  Affiliation Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany

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• Lorna M. Lopez,

  Affiliation Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom

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• Jennifer E. Huffman,

  Affiliation MRC Human Genetics, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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• Stefan Enroth,

  Affiliation Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, SciLifeLab, Uppsala University, Uppsala, Sweden

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• Yohan Bossé,

  Affiliation Institut Universitaire de Cardiologie et de Pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec City, Canada

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• Ke Hao,

  Affiliation Department of Genetics and Genomic Sciences, Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

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• Wim Timens,

  Affiliation Department of Pathology and Medical Biology, University Medical Center Groningen, GRIAC Research Institute, University of Groningen, Groningen, The Netherlands

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• Ulf Gyllensten,

  Affiliation Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, SciLifeLab, Uppsala University, Uppsala, Sweden

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• Ozren Polasek,

  Affiliation Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia

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• James F. Wilson,

  Affiliation Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, United Kingdom

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• Igor Rudan,

  Affiliation Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, United Kingdom

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• Caroline Hayward,

  Affiliation MRC Human Genetics, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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• Andrew J. Sandford,

  Affiliation James Hogg Research Centre, Institute for Heart and Lung Health, University of British Columbia, Vancouver, Canada

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• Ian J. Deary,

  Affiliation Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom

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• Beate Koch,

  Affiliation Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany

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• Eva Reischl,

  Affiliation Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany

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• Holger Schulz,

  Affiliation Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany

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• Jennie Hui,

  Affiliations School of Population Health, University of Western Australia, Perth, Australia, Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia, Busselton Population Medical Research Foundation, Perth, Australia

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• Alan L. James,

  Affiliations West Australian Sleep Disorders Research Institute, Perth, Australia, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia

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• Thierry Rochat,

  Affiliation Division of Pulmonary Medicine, University Hospital of Geneva, Geneva, Switzerland

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• Erich W. Russi,

  Affiliation Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland

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• Marjo-Riitta Jarvelin,

  Affiliations Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom, Institute of Health Sciences, University of Oulu, Oulu, Finland, Biocenter Oulu, University of Oulu, Oulu, Finland, Unit of Primary Care, Oulu University Hospital, Oulu, Finland, Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland

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• David P. Strachan,

  Affiliation Division of Population Health Sciences and Education, St George's, University of London, London, United Kingdom

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• Ian P. Hall,

  Affiliation Division of Therapeutics and Molecular Medicine, Queen's Medical Centre, Nottingham, United Kingdom

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• Martin D. Tobin,

  Affiliation Departments of Health Sciences and Genetics, University of Leicester, Leicester, United Kingdom

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• Morten Dahl,

  Affiliation Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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• Sune Fallgaard Nielsen,

  Affiliation Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark

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• Børge G. Nordestgaard,

  Affiliation Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark

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• Florian Kronenberg,

  Affiliation Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria

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• Maurizio Luisetti,

  Affiliation Center for Diagnosis of Inherited Alpha1-antitrypsin Deficiency, Institute for Respiratory Disease, IRCCS San Matteo Hospital Foundation, University of Pavia, Pavia, Italy

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•  [ ... ],
• Nicole M. Probst-Hensch

  * E-mail: nicole.probst@unibas.ch

  Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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