Methylation of Histone H3 on Lysine 79 Associates with a Group of Replication Origins and Helps Limit DNA Replication Once per Cell Cycle

Haiqing Fu; Alika K. Maunakea; Melvenia M. Martin; Liang Huang; Ya Zhang; Michael Ryan; RyangGuk Kim; Chii Meil Lin; Keji Zhao; Mirit I. Aladjem

doi:10.1371/journal.pgen.1003542

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Open Access

Peer-reviewed

Research Article

Methylation of Histone H3 on Lysine 79 Associates with a Group of Replication Origins and Helps Limit DNA Replication Once per Cell Cycle

Haiqing Fu,

Affiliation Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America
⨯
Alika K. Maunakea,

Affiliation Systems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, United States of America
⨯
Melvenia M. Martin,

Affiliation Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America
⨯
Liang Huang,

Affiliation Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America
⨯
Ya Zhang,

Affiliation Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America
⨯
Michael Ryan,

Affiliation InSilico Solutions, Fairfax, Virginia, United States of America
⨯
RyangGuk Kim,

Affiliation InSilico Solutions, Fairfax, Virginia, United States of America
⨯
Chii Meil Lin,

Affiliation Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America
⨯
Keji Zhao,

Affiliation Systems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, United States of America
⨯
Mirit I. Aladjem

* E-mail: aladjemm@mail.nih.gov

Affiliation Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America
⨯

Methylation of Histone H3 on Lysine 79 Associates with a Group of Replication Origins and Helps Limit DNA Replication Once per Cell Cycle

Haiqing Fu,
Alika K. Maunakea,
Melvenia M. Martin,
Liang Huang,
Ya Zhang,
Michael Ryan,
RyangGuk Kim,
Chii Meil Lin,
Keji Zhao,
Mirit I. Aladjem

Published: June 6, 2013
https://doi.org/10.1371/journal.pgen.1003542

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DNA replication
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DNA methylation
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Cell cycle and cell division
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Chromatin
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Small interfering RNA
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Transfection
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