Distinct Neuroblastoma-associated Alterations of PHOX2B Impair Sympathetic Neuronal Differentiation in Zebrafish Models

Desheng Pei; William Luther; Wenchao Wang; Barry H. Paw; Rodney A. Stewart; Rani E. George

doi:10.1371/journal.pgen.1003533

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Peer-reviewed

Research Article

Distinct Neuroblastoma-associated Alterations of PHOX2B Impair Sympathetic Neuronal Differentiation in Zebrafish Models

Desheng Pei ,

Contributed equally to this work with: Desheng Pei, William Luther

Affiliation Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
William Luther ,

Contributed equally to this work with: Desheng Pei, William Luther

Affiliation Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Wenchao Wang,

Affiliation Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Barry H. Paw,

Affiliations Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Hematology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Rodney A. Stewart,

Affiliation Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America
⨯
Rani E. George

* E-mail: rani_george@dfci.harvard.edu

Affiliation Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Distinct Neuroblastoma-associated Alterations of PHOX2B Impair Sympathetic Neuronal Differentiation in Zebrafish Models

Desheng Pei,
William Luther,
Wenchao Wang,
Barry H. Paw,
Rodney A. Stewart,
Rani E. George

Published: June 6, 2013
https://doi.org/10.1371/journal.pgen.1003533

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Frameshift mutation
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Cell differentiation
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