Global DNA Hypermethylation in Down Syndrome Placenta

Shengnan Jin; Yew Kok Lee; Yen Ching Lim; Zejun Zheng; Xueqin Michelle Lin; Desmond P. Y. Ng; Joanna D. Holbrook; Hai Yang Law; Kenneth Y. C. Kwek; George S. H. Yeo; Chunming Ding

doi:10.1371/journal.pgen.1003515

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Open Access

Peer-reviewed

Research Article

Global DNA Hypermethylation in Down Syndrome Placenta

Shengnan Jin ,

Contributed equally to this work with: Shengnan Jin, Yew Kok Lee

Affiliation Growth, Development and Metabolism Program, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore
⨯
Yew Kok Lee ,

Contributed equally to this work with: Shengnan Jin, Yew Kok Lee

Affiliation Growth, Development and Metabolism Program, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore
⨯
Yen Ching Lim,

Affiliation Growth, Development and Metabolism Program, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore
⨯
Zejun Zheng,

Affiliation Growth, Development and Metabolism Program, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore
⨯
Xueqin Michelle Lin,

Affiliation Growth, Development and Metabolism Program, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore
⨯
Desmond P. Y. Ng,

Affiliation Growth, Development and Metabolism Program, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore
⨯
Joanna D. Holbrook,

Affiliation Growth, Development and Metabolism Program, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore
⨯
Hai Yang Law,

Affiliation KK Women's and Children's Hospital, Singapore
⨯
Kenneth Y. C. Kwek,

Affiliation KK Women's and Children's Hospital, Singapore
⨯
George S. H. Yeo,

Affiliation KK Women's and Children's Hospital, Singapore
⨯
Chunming Ding

* E-mail: cmding@gmail.com

Affiliation Growth, Development and Metabolism Program, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore
⨯

Global DNA Hypermethylation in Down Syndrome Placenta

Shengnan Jin,
Yew Kok Lee,
Yen Ching Lim,
Zejun Zheng,
Xueqin Michelle Lin,
Desmond P. Y. Ng,
Joanna D. Holbrook,
Hai Yang Law,
Kenneth Y. C. Kwek,
George S. H. Yeo

Published: June 6, 2013
https://doi.org/10.1371/journal.pgen.1003515

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Down syndrome
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Gene expression
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