Aconitase Causes Iron Toxicity in Drosophila pink1 Mutants

Giovanni Esposito; Melissa Vos; Sven Vilain; Jef Swerts; Jorge De Sousa Valadas; Stefanie Van Meensel; Onno Schaap; Patrik Verstreken

doi:10.1371/journal.pgen.1003478

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Open Access

Peer-reviewed

Research Article

Aconitase Causes Iron Toxicity in Drosophila pink1 Mutants

Giovanni Esposito,

Affiliations VIB Center for the Biology of Disease, Leuven, Belgium, KU Leuven, Center for Human Genetics and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium
⨯
Melissa Vos,

Affiliations VIB Center for the Biology of Disease, Leuven, Belgium, KU Leuven, Center for Human Genetics and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium
⨯
Sven Vilain,

Affiliations VIB Center for the Biology of Disease, Leuven, Belgium, KU Leuven, Center for Human Genetics and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium
⨯
Jef Swerts,

Affiliations VIB Center for the Biology of Disease, Leuven, Belgium, KU Leuven, Center for Human Genetics and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium
⨯
Jorge De Sousa Valadas,

Affiliations VIB Center for the Biology of Disease, Leuven, Belgium, KU Leuven, Center for Human Genetics and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium
⨯
Stefanie Van Meensel,

Affiliations VIB Center for the Biology of Disease, Leuven, Belgium, KU Leuven, Center for Human Genetics and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium
⨯
Onno Schaap,

Affiliations VIB Center for the Biology of Disease, Leuven, Belgium, KU Leuven, Center for Human Genetics and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium
⨯
Patrik Verstreken

* E-mail: patrik.verstreken@cme.vib-kuleuven.be

Affiliations VIB Center for the Biology of Disease, Leuven, Belgium, KU Leuven, Center for Human Genetics and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium
⨯

Aconitase Causes Iron Toxicity in Drosophila pink1 Mutants

Giovanni Esposito,
Melissa Vos,
Sven Vilain,
Jef Swerts,
Jorge De Sousa Valadas,
Stefanie Van Meensel,
Onno Schaap,
Patrik Verstreken

Published: April 25, 2013
https://doi.org/10.1371/journal.pgen.1003478

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Mitochondria
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Neurons
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Heterozygosity
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Neuronal morphology
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Superoxides
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Parkinson disease
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Toxicity
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Drosophila melanogaster
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