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Open Access
Peer-reviewed
Research Article
Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases
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Ricardo C. Ferreira ,
Contributed equally to this work with: Ricardo C. Ferreira, Daniel F. Freitag
Affiliation Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
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Daniel F. Freitag ,
Contributed equally to this work with: Ricardo C. Ferreira, Daniel F. Freitag
Affiliation Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom
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Antony J. Cutler,
Affiliation Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
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Joanna M. M. Howson,
Affiliation Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom
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Daniel B. Rainbow,
Affiliation Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
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Deborah J. Smyth,
Affiliation Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
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Stephen Kaptoge,
Affiliation Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom
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Pamela Clarke,
Affiliation Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
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Charlotte Boreham,
Affiliation Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
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Richard M. Coulson,
Affiliation Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
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Marcin L. Pekalski,
Affiliation Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
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Wei-Min Chen,
Affiliation Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America
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Suna Onengut-Gumuscu,
Affiliation Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America
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Stephen S. Rich,
Affiliation Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America
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Adam S. Butterworth,
Affiliation Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom
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Anders Malarstig,
Affiliations Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom, Precision Medicine, Pfizer Global Research and Development, Cambridge, United Kingdom
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John Danesh,
Affiliation Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom
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John A. Todd
* E-mail: john.todd@cimr.cam.ac.uk
Affiliation Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
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Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases
- Ricardo C. Ferreira,
- Daniel F. Freitag,
- Antony J. Cutler,
- Joanna M. M. Howson,
- Daniel B. Rainbow,
- Deborah J. Smyth,
- Stephen Kaptoge,
- Pamela Clarke,
- Charlotte Boreham,
- Richard M. Coulson
- Published: April 4, 2013
- https://doi.org/10.1371/journal.pgen.1003444