Confounding by Repetitive Elements and CpG Islands Does Not Explain the Association between Hypomethylation and Genomic Instability

R. Alan Harris; Chad Shaw; Jian Li; Sau Wai Cheung; Cristian Coarfa; Mira Jeong; Margaret A. Goodell; Lisa D. White; Ankita Patel; Sung-Hae Kang; A. Craig Chinault; Tomasz Gambin; Anna Gambin; James R. Lupski; Aleksandar Milosavljevic

doi:10.1371/journal.pgen.1003333

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Confounding by Repetitive Elements and CpG Islands Does Not Explain the Association between Hypomethylation and Genomic Instability

R. Alan Harris,

Affiliations Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Chad Shaw,

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Jian Li,

Affiliations Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Sau Wai Cheung,

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
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Cristian Coarfa,

Affiliations Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Mira Jeong,

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Margaret A. Goodell,

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
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Lisa D. White,

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Ankita Patel,

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Sung-Hae Kang,

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
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A. Craig Chinault,

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
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Tomasz Gambin,

Affiliation Institute of Computer Science, Warsaw University of Technology, Warsaw, Poland
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Anna Gambin,

Affiliation Institute of Informatics, Warsaw University, Warsaw, Poland
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James R. Lupski,

Affiliations Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America, Texas Children's Hospital, Houston, Texas, United States of America
⨯
Aleksandar Milosavljevic

* E-mail: amilosav@bcm.edu

Affiliations Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
⨯

Confounding by Repetitive Elements and CpG Islands Does Not Explain the Association between Hypomethylation and Genomic Instability

R. Alan Harris,
Chad Shaw,
Jian Li,
Sau Wai Cheung,
Cristian Coarfa,
Mira Jeong,
Margaret A. Goodell,
Lisa D. White,
Ankita Patel,
Sung-Hae Kang

Published: February 28, 2013
https://doi.org/10.1371/journal.pgen.1003333

Reader Comments (16)

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07 Dec 2015
01:45 GMT
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Independent validation of the association between hypomethylation and genomic instability Posted by amilosav on 07 Dec 2015 at 01:45 GMT
9 Responses

02 Apr 2014
20:28 GMT
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A full explanation of the technical biases in this study Posted by asharp on 03 Mar 2013 at 05:12 GMT
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05 Mar 2013
14:11 GMT
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A short primer on multiple regression Posted by amilosav on 05 Mar 2013 at 14:11 GMT
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02 Mar 2013
18:58 GMT
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Reply to Harris et al. by Andrew Sharp Posted by asharp on 28 Feb 2013 at 22:23 GMT

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