Quantitative Analysis of Histone Modifications: Formaldehyde Is a Source of Pathological N6-Formyllysine That Is Refractory to Histone Deacetylases

Open Access

Peer-reviewed

Research Article

Quantitative Analysis of Histone Modifications: Formaldehyde Is a Source of Pathological N⁶-Formyllysine That Is Refractory to Histone Deacetylases

Bahar Edrissi,

Affiliation Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Koli Taghizadeh,

Affiliation Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Peter C. Dedon

* E-mail: pcdedon@mit.edu

Affiliations Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Lysine
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Histones
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DNA-binding proteins
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Formaldehyde
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Acetylation
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High performance liquid chromatography
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Oxidation
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Protein extraction
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