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Open Access
Peer-reviewed
Research Article
miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1
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Christian Lacks Lino Cardenas ,
Contributed equally to this work with: Christian Lacks Lino Cardenas, Imène Sarah Henaoui, Bernard Mari, Nicolas Pottier
Affiliation EA4483, Faculté de Médecine de Lille, Pole Recherche, Lille, France
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Imène Sarah Henaoui ,
Contributed equally to this work with: Christian Lacks Lino Cardenas, Imène Sarah Henaoui, Bernard Mari, Nicolas Pottier
Affiliations Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, UMR-7275, Valbonne Sophia-Antipolis, France, Université de Nice Sophia-Antipolis, Nice, France
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Elisabeth Courcot,
Affiliation EA4483, Faculté de Médecine de Lille, Pole Recherche, Lille, France
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Christoph Roderburg,
Affiliation Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany
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Christelle Cauffiez,
Affiliation EA4483, Faculté de Médecine de Lille, Pole Recherche, Lille, France
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Sébastien Aubert,
Affiliations Institut National de la Santé et de la Recherche Médicale, U837, Jean-Pierre Aubert Research Center, Equipe 5 “Mucines, Différentiation et Cancérogenèse Épithéliales”, Lille, France, Pôle de Pathologie, CHRU Lille, Lille, France, Faculté de Médecine, Université de Lille 2, Lille, France
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Marie-Christine Copin,
Affiliations Institut National de la Santé et de la Recherche Médicale, U837, Jean-Pierre Aubert Research Center, Equipe 5 “Mucines, Différentiation et Cancérogenèse Épithéliales”, Lille, France, Pôle de Pathologie, CHRU Lille, Lille, France, Faculté de Médecine, Université de Lille 2, Lille, France
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Benoit Wallaert,
Affiliation Service de Pneumologie et Immunoallergologie, CHRU Lille, Lille, France
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François Glowacki,
Affiliation EA4483, Faculté de Médecine de Lille, Pole Recherche, Lille, France
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Edmone Dewaeles,
Affiliation EA4483, Faculté de Médecine de Lille, Pole Recherche, Lille, France
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Jadranka Milosevic,
Affiliation Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Julien Maurizio,
Affiliations Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, UMR-7275, Valbonne Sophia-Antipolis, France, Université de Nice Sophia-Antipolis, Nice, France
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John Tedrow,
Affiliation Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Brice Marcet,
Affiliations Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, UMR-7275, Valbonne Sophia-Antipolis, France, Université de Nice Sophia-Antipolis, Nice, France
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Jean-Marc Lo-Guidice,
Affiliation EA4483, Faculté de Médecine de Lille, Pole Recherche, Lille, France
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Naftali Kaminski,
Affiliation Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Pascal Barbry,
Affiliations Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, UMR-7275, Valbonne Sophia-Antipolis, France, Université de Nice Sophia-Antipolis, Nice, France
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Tom Luedde,
Affiliation Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany
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Michael Perrais,
Affiliations Institut National de la Santé et de la Recherche Médicale, U837, Jean-Pierre Aubert Research Center, Equipe 5 “Mucines, Différentiation et Cancérogenèse Épithéliales”, Lille, France, Faculté de Médecine, Université de Lille 2, Lille, France
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Bernard Mari ,
Contributed equally to this work with: Christian Lacks Lino Cardenas, Imène Sarah Henaoui, Bernard Mari, Nicolas Pottier
* E-mail: mari@unice.fr (B Mari) (BM); nico_pottier@yahoo.fr (N Pottier) (NP)
Affiliations Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, UMR-7275, Valbonne Sophia-Antipolis, France, Université de Nice Sophia-Antipolis, Nice, France
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Nicolas Pottier
Contributed equally to this work with: Christian Lacks Lino Cardenas, Imène Sarah Henaoui, Bernard Mari, Nicolas Pottier
* E-mail: mari@unice.fr (B Mari) (BM); nico_pottier@yahoo.fr (N Pottier) (NP)
Affiliation EA4483, Faculté de Médecine de Lille, Pole Recherche, Lille, France
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miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1
- Christian Lacks Lino Cardenas,
- Imène Sarah Henaoui,
- Elisabeth Courcot,
- Christoph Roderburg,
- Christelle Cauffiez,
- Sébastien Aubert,
- Marie-Christine Copin,
- Benoit Wallaert,
- François Glowacki,
- Edmone Dewaeles
- Published: February 14, 2013
- https://doi.org/10.1371/journal.pgen.1003291