An Evolutionarily Conserved Synthetic Lethal Interaction Network Identifies FEN1 as a Broad-Spectrum Target for Anticancer Therapeutic Development

• Derek M. van Pel,

  Affiliations Michael Smith Laboratories, University of British Columbia, Vancouver, Canada, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada

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• Irene J. Barrett,

  Affiliation Michael Smith Laboratories, University of British Columbia, Vancouver, Canada

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• Yoko Shimizu,

  Affiliation Department of Screening, Centre for Drug Research and Development, Vancouver, Canada

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• Babu V. Sajesh,

  Affiliation Department of Screening, Centre for Drug Research and Development, Vancouver, Canada

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• Brent J. Guppy,

  Affiliation Department of Screening, Centre for Drug Research and Development, Vancouver, Canada

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• Tom Pfeifer,

  Affiliation Department of Screening, Centre for Drug Research and Development, Vancouver, Canada

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• Kirk J. McManus,

  Affiliation Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Canada

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• Philip Hieter

  * E-mail: hieter@msl.ubc.ca

  Affiliation Michael Smith Laboratories, University of British Columbia, Vancouver, Canada

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