TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo

• Fernando Gómez-Herreros ,

  Contributed equally to this work with: Fernando Gómez-Herreros, Rocío Romero-Granados

  Affiliation Genome Damage and Stability Centre, University of Sussex, Falmer, United Kingdom

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• Rocío Romero-Granados ,

  Contributed equally to this work with: Fernando Gómez-Herreros, Rocío Romero-Granados

  Affiliation Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), CSIC–Universidad de Sevilla (Departamento de Genética), Sevilla, Spain

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• Zhihong Zeng,

  Affiliation Genome Damage and Stability Centre, University of Sussex, Falmer, United Kingdom

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• Alejandro Álvarez-Quilón,

  Affiliation Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), CSIC–Universidad de Sevilla (Departamento de Genética), Sevilla, Spain

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• Cristina Quintero,

  Affiliation Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), CSIC–Universidad de Sevilla (Departamento de Genética), Sevilla, Spain

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• Limei Ju,

  Affiliation Genome Damage and Stability Centre, University of Sussex, Falmer, United Kingdom

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• Lieve Umans,

  Affiliation Laboratory of Molecular Biology (Celgen), Department of Development and Regeneration, University of Leuven, Leuven, Belgium

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• Liesbeth Vermeire,

  Affiliation Laboratory of Molecular Biology (Celgen), Department of Development and Regeneration, University of Leuven, Leuven, Belgium

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• Danny Huylebroeck,

  Affiliation Laboratory of Molecular Biology (Celgen), Department of Development and Regeneration, University of Leuven, Leuven, Belgium

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• Keith W. Caldecott ,

  * E-mail: k.w.caldecott@sussex.ac.uk (KWC); felipe.cortes@cabimer.es (FC-L)

  Affiliation Genome Damage and Stability Centre, University of Sussex, Falmer, United Kingdom

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• Felipe Cortés-Ledesma

  * E-mail: k.w.caldecott@sussex.ac.uk (KWC); felipe.cortes@cabimer.es (FC-L)

  Affiliation Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), CSIC–Universidad de Sevilla (Departamento de Genética), Sevilla, Spain

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