Directed Evolution of a Model Primordial Enzyme Provides Insights into the Development of the Genetic Code

• Manuel M. Müller,

  Current address: Department of Chemistry, Princeton University, Princeton, New Jersey, United States of America

  Affiliation Laboratory of Organic Chemistry, ETH Zurich, Zurich, Switzerland

  ⨯
• Jane R. Allison,

  Current address: Centre for Theoretical Chemistry and Physics, Massey University Albany, Auckland, New Zealand

  Affiliation Laboratory of Physical Chemistry, ETH Zurich, Zurich, Switzerland

  ⨯
• Narupat Hongdilokkul,

  Affiliation Laboratory of Organic Chemistry, ETH Zurich, Zurich, Switzerland

  ⨯
• Laurent Gaillon,

  Affiliation Institut de Génomique, CEA, Evry, France

  ⨯
• Peter Kast,

  Affiliation Laboratory of Organic Chemistry, ETH Zurich, Zurich, Switzerland

  ⨯
• Wilfred F. van Gunsteren,

  Affiliation Laboratory of Physical Chemistry, ETH Zurich, Zurich, Switzerland

  ⨯
• Philippe Marlière,

  Affiliation Heurisko USA, Newark, Delaware, United States of America

  ⨯
• Donald Hilvert

  * E-mail: hilvert@org.chem.ethz.ch

  Affiliation Laboratory of Organic Chemistry, ETH Zurich, Zurich, Switzerland

  ⨯