Integrative Genomics in Combination with RNA Interference Identifies Prognostic and Functionally Relevant Gene Targets for Oral Squamous Cell Carcinoma

Chang Xu; Pei Wang; Yan Liu; Yuzheng Zhang; Wenhong Fan; Melissa P. Upton; Pawadee Lohavanichbutr; John R. Houck; David R. Doody; Neal D. Futran; Lue Ping Zhao; Stephen M. Schwartz; Chu Chen; Eduardo Méndez

doi:10.1371/journal.pgen.1003169

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Open Access

Peer-reviewed

Research Article

Integrative Genomics in Combination with RNA Interference Identifies Prognostic and Functionally Relevant Gene Targets for Oral Squamous Cell Carcinoma

Chang Xu,

Affiliations Department of Otolaryngology–Head and Neck Surgery, University of Washington, Seattle, Washington, United States of America, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Pei Wang,

Affiliations Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
⨯
Yan Liu,

Affiliation Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Yuzheng Zhang,

Affiliation Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Wenhong Fan,

Affiliation Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Melissa P. Upton,

Affiliation Department of Pathology, University of Washington, Seattle, Washington, United States of America
⨯
Pawadee Lohavanichbutr,

Affiliation Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
John R. Houck,

Affiliation Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
David R. Doody,

Affiliation Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Neal D. Futran,

Affiliation Department of Otolaryngology–Head and Neck Surgery, University of Washington, Seattle, Washington, United States of America
⨯
Lue Ping Zhao,

Affiliations Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
⨯
Stephen M. Schwartz,

Affiliations Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
⨯
Chu Chen,

Affiliations Department of Otolaryngology–Head and Neck Surgery, University of Washington, Seattle, Washington, United States of America, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
⨯
Eduardo Méndez

* E-mail: edmendez@u.washington.edu

Affiliations Department of Otolaryngology–Head and Neck Surgery, University of Washington, Seattle, Washington, United States of America, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Surgery and Perioperative Care Service, VA Puget Sound Health Care System, Seattle, Washington, United States of America
⨯

Integrative Genomics in Combination with RNA Interference Identifies Prognostic and Functionally Relevant Gene Targets for Oral Squamous Cell Carcinoma

Chang Xu,
Pei Wang,
Yan Liu,
Yuzheng Zhang,
Wenhong Fan,
Melissa P. Upton,
Pawadee Lohavanichbutr,
John R. Houck,
David R. Doody,
Neal D. Futran

Published: January 17, 2013
https://doi.org/10.1371/journal.pgen.1003169

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