Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse

• Fiona McMurray ,

  Contributed equally to this work with: Fiona McMurray, Chris D. Church, Rachel Larder, George Nicholson

  Affiliation MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

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• Chris D. Church ,

  Contributed equally to this work with: Fiona McMurray, Chris D. Church, Rachel Larder, George Nicholson

  Affiliation MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

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• Rachel Larder ,

  Contributed equally to this work with: Fiona McMurray, Chris D. Church, Rachel Larder, George Nicholson

  Affiliation University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

  ⨯
• George Nicholson ,

  Contributed equally to this work with: Fiona McMurray, Chris D. Church, Rachel Larder, George Nicholson

  Affiliations MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom, Department of Statistics, University of Oxford, Oxford, United Kingdom

  ⨯
• Sara Wells,

  Affiliation MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

  ⨯
• Lydia Teboul,

  Affiliation MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

  ⨯
• Y. C. Loraine Tung,

  Affiliation University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

  ⨯
• Debra Rimmington,

  Affiliation University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

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• Fatima Bosch,

  Affiliations Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

  ⨯
• Veronica Jimenez,

  Affiliations Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

  ⨯
• Giles S. H. Yeo,

  Affiliation University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

  ⨯
• Stephen O'Rahilly,

  Affiliation University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

  ⨯
• Frances M. Ashcroft ,

  ¶These authors also contributed equally to this work.

  Affiliation Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

  ⨯
• Anthony P. Coll ,

  ¶These authors also contributed equally to this work.

  Affiliation University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

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• Roger D. Cox

  * E-mail: r.cox@har.mrc.ac.uk

  ¶These authors also contributed equally to this work.

  Affiliation MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

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