Base Damage within Single-Strand DNA Underlies In Vivo Hypermutability Induced by a Ubiquitous Environmental Agent

Open Access

Peer-reviewed

Research Article

Kin Chan,

Affiliation Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
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Joan F. Sterling,

Affiliation Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
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Steven A. Roberts,

Affiliation Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
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Ashok S. Bhagwat,

Affiliation Department of Chemistry, Wayne State University, Detroit, Michigan, United States of America
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Michael A. Resnick,

Affiliation Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
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Dmitry A. Gordenin

* E-mail: gordenin@niehs.nih.gov

Affiliation Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
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Mutagenesis
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Cytosine
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Uracils
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DNA damage
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Reporter genes
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Point mutation
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Sulfites
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Mutation
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