Dissection of a Quantitative Trait Locus for PR Interval Duration Identifies Tnni3k as a Novel Modulator of Cardiac Conduction

Elisabeth M. Lodder; Brendon P. Scicluna; Annalisa Milano; Albert Y. Sun; Hao Tang; Carol Ann Remme; Perry D. Moerland; Michael W. T. Tanck; Geoffrey S. Pitt; Douglas A. Marchuk; Connie R. Bezzina

doi:10.1371/journal.pgen.1003113

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Open Access

Peer-reviewed

Research Article

Dissection of a Quantitative Trait Locus for PR Interval Duration Identifies Tnni3k as a Novel Modulator of Cardiac Conduction

Elisabeth M. Lodder ,

Contributed equally to this work with: Elisabeth M. Lodder, Brendon P. Scicluna

Affiliation Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Brendon P. Scicluna ,

Contributed equally to this work with: Elisabeth M. Lodder, Brendon P. Scicluna

Affiliation Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Annalisa Milano,

Affiliation Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Albert Y. Sun,

Affiliation The Ion Channel Research Unit, Department of Medicine, Duke University, Durham, North Carolina, United States of America
⨯
Hao Tang,

Affiliation Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America
⨯
Carol Ann Remme,

Affiliation Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Perry D. Moerland,

Affiliation Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Michael W. T. Tanck,

Affiliation Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Geoffrey S. Pitt,

Affiliation The Ion Channel Research Unit, Department of Medicine, Duke University, Durham, North Carolina, United States of America
⨯
Douglas A. Marchuk,

Affiliation Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America
⨯
Connie R. Bezzina

* E-mail: C.R.Bezzina@amc.uva.nl

Affiliation Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯

Dissection of a Quantitative Trait Locus for PR Interval Duration Identifies Tnni3k as a Novel Modulator of Cardiac Conduction

Elisabeth M. Lodder,
Brendon P. Scicluna,
Annalisa Milano,
Albert Y. Sun,
Hao Tang,
Carol Ann Remme,
Perry D. Moerland,
Michael W. T. Tanck,
Geoffrey S. Pitt,
Douglas A. Marchuk

Published: December 6, 2012
https://doi.org/10.1371/journal.pgen.1003113

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