A Genome-Wide RNAi Screen Reveals MAP Kinase Phosphatases as Key ERK Pathway Regulators during Embryonic Stem Cell Differentiation

Open Access

Peer-reviewed

Research Article

Shen-Hsi Yang,

Affiliation Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
⨯
Tuzer Kalkan,

Affiliation Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
⨯
Claire Morrisroe,

Affiliation Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
⨯
Austin Smith,

Affiliation Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
⨯
Andrew D. Sharrocks

* E-mail: a.d.sharrocks@manchester.ac.uk

Affiliation Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
⨯

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Small interfering RNA
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ERK signaling cascade
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Pluripotency
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Genetic screens
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Cell differentiation
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Embryonic stem cells
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Gene expression
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Phosphatases
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