Selective Pressure Causes an RNA Virus to Trade Reproductive Fitness for Increased Structural and Thermal Stability of a Viral Enzyme

• Moshe Dessau ,

  Contributed equally to this work with: Moshe Dessau, Daniel Goldhill

  Affiliation Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

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• Daniel Goldhill ,

  Contributed equally to this work with: Moshe Dessau, Daniel Goldhill

  Affiliation Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America

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• Robert L. McBride,

  Current address: Sapphire Energy, San Diego, California, United States of America

  Affiliation Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America

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• Paul E. Turner ,

  * E-mail: paul.turner@yale.edu (PET); yorgo.modis@yale.edu (YM)

  Affiliation Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America

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• Yorgo Modis

  * E-mail: paul.turner@yale.edu (PET); yorgo.modis@yale.edu (YM)

  Affiliation Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

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