Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function

• Dana B. Hancock ,

  Contributed equally to this work with: Dana B. Hancock, María Soler Artigas, Sina A. Gharib, Amanda Henry, Ani Manichaikul, Adaikalavan Ramasamy, Daan W. Loth

  Affiliations Behavioral Health Epidemiology Program, Research Triangle Institute International, Research Triangle Park, North Carolina, United States of America, Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America

  ⨯
• María Soler Artigas ,

  Contributed equally to this work with: Dana B. Hancock, María Soler Artigas, Sina A. Gharib, Amanda Henry, Ani Manichaikul, Adaikalavan Ramasamy, Daan W. Loth

  Affiliation Departments of Health Sciences and Genetics, University of Leicester, Leicester, United Kingdom

  ⨯
• Sina A. Gharib ,

  Contributed equally to this work with: Dana B. Hancock, María Soler Artigas, Sina A. Gharib, Amanda Henry, Ani Manichaikul, Adaikalavan Ramasamy, Daan W. Loth

  Affiliations Center for Lung Biology, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America

  ⨯
• Amanda Henry ,

  Contributed equally to this work with: Dana B. Hancock, María Soler Artigas, Sina A. Gharib, Amanda Henry, Ani Manichaikul, Adaikalavan Ramasamy, Daan W. Loth

  Affiliation Division of Therapeutics and Molecular Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom

  ⨯
• Ani Manichaikul ,

  Contributed equally to this work with: Dana B. Hancock, María Soler Artigas, Sina A. Gharib, Amanda Henry, Ani Manichaikul, Adaikalavan Ramasamy, Daan W. Loth

  Affiliations Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America, Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, Virginia, United States of America

  ⨯
• Adaikalavan Ramasamy ,

  Contributed equally to this work with: Dana B. Hancock, María Soler Artigas, Sina A. Gharib, Amanda Henry, Ani Manichaikul, Adaikalavan Ramasamy, Daan W. Loth

  Affiliations Respiratory Epidemiology and Public Health, Imperial College London, London, United Kingdom, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom, Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London, United Kingdom

  ⨯
• Daan W. Loth ,

  Contributed equally to this work with: Dana B. Hancock, María Soler Artigas, Sina A. Gharib, Amanda Henry, Ani Manichaikul, Adaikalavan Ramasamy, Daan W. Loth

  Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Inspectorate of Healthcare, The Hague, The Netherlands

  ⨯
• Medea Imboden,

  Affiliations Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

  ⨯
• Beate Koch,

  Affiliation Department of Internal Medicine B, University Hospital Greifswald, Greifswald, Germany

  ⨯
• Wendy L. McArdle,

  Affiliation ALSPAC, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

  ⨯
• Albert V. Smith,

  Affiliations Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

  ⨯
• Joanna Smolonska,

  Affiliation Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

  ⨯
• Akshay Sood,

  Affiliation Department of Medicine, University of New Mexico, Albuquerque, New Mexico, United States of America

  ⨯
• Wenbo Tang,

  Affiliation Division of Nutritional Sciences, Cornell University, Ithaca, New York, United States of America

  ⨯
• Jemma B. Wilk,

  Affiliations Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America

  ⨯
• Guangju Zhai,

  Affiliations Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada

  ⨯
• Jing Hua Zhao,

  Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom

  ⨯
• Hugues Aschard,

  Affiliation Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Kristin M. Burkart,

  Affiliation Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

  ⨯
• Ivan Curjuric,

  Affiliations Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

  ⨯
• Mark Eijgelsheim,

  Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

  ⨯
• Paul Elliott,

  Affiliations Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom, MRC-HPA Centre for Environment and Health, Imperial College London, London, United Kingdom

  ⨯
• Xiangjun Gu,

  Affiliation Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

  ⨯
• Tamara B. Harris,

  Affiliation National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Christer Janson,

  Affiliation Department of Medical Sciences, Respiratory Medicine, Uppsala University, Uppsala, Sweden

  ⨯
• Georg Homuth,

  Affiliation Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald, Greifswald, Germany

  ⨯
• Pirro G. Hysi,

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

  ⨯
• Jason Z. Liu,

  Affiliation Department of Statistics, University of Oxford, United Kingdom

  ⨯
• Laura R. Loehr,

  Affiliation Gillings School of Global Public Health, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

  ⨯
• Kurt Lohman,

  Affiliation Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

  ⨯
• Ruth J. F. Loos,

  Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom

  ⨯
• Alisa K. Manning,

  Affiliations Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Kristin D. Marciante,

  Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

  ⨯
• Ma'en Obeidat,

  Affiliation Division of Therapeutics and Molecular Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom

  ⨯
• Dirkje S. Postma,

  Affiliations Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, GRIAC Research Institute, University Medical Center Groningen, Groningen, The Netherlands

  ⨯
• Melinda C. Aldrich,

  Affiliation Department of Thoracic Surgery and Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

  ⨯
• Guy G. Brusselle,

  Affiliation Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium

  ⨯
• Ting-hsu Chen,

  Affiliations Section of Pulmonary and Critical Care Medicine, Department of Medicine, Veterans Administration Boston Healthcare System, Boston, Massachusetts, United States of America, The Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

  ⨯
• Gudny Eiriksdottir,

  Affiliation Icelandic Heart Association, Kopavogur, Iceland

  ⨯
• Nora Franceschini,

  Affiliation Gillings School of Global Public Health, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

  ⨯
• Joachim Heinrich,

  Affiliation Institute of Epidemiology I, Helmholtz Zentrum München, Munich, Germany

  ⨯
• Jerome I. Rotter,

  Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

  ⨯
• Cisca Wijmenga,

  Affiliation Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

  ⨯
• O. Dale Williams,

  Affiliation Department of Biostatistics, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, Florida, United States of America

  ⨯
• Amy R. Bentley,

  Affiliation Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Albert Hofman,

  Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

  ⨯
• Cathy C. Laurie,

  Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

  ⨯
• Thomas Lumley,

  Affiliation Department of Statistics, University of Auckland, Auckland, New Zealand

  ⨯
• Alanna C. Morrison,

  Affiliation Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

  ⨯
• Bonnie R. Joubert,

  Affiliation Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America

  ⨯
• Fernando Rivadeneira,

  Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Netherlands Genomics Initiative (NGI)–sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands

  ⨯
• David J. Couper,

  Affiliation Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

  ⨯
• Stephen B. Kritchevsky,

  Affiliation Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

  ⨯
• Yongmei Liu,

  Affiliation Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

  ⨯
• Matthias Wjst,

  Affiliations Institute of Lung Biology and Disease, Comprehensive Pneumology Center, Helmholtz Zentrum München, Neuherberg, Germany, Institute for Medical Statistics and Epidemiology (IMSE), Technical University Munich, Munich, Germany

  ⨯
• Louise V. Wain,

  Affiliation Departments of Health Sciences and Genetics, University of Leicester, Leicester, United Kingdom

  ⨯
• Judith M. Vonk,

  Affiliations GRIAC Research Institute, University Medical Center Groningen, Groningen, The Netherlands, Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, The LifeLines Cohort Study, Groningen, The Netherlands

  ⨯
• André G. Uitterlinden,

  Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Netherlands Genomics Initiative (NGI)–sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands

  ⨯
• Thierry Rochat,

  Affiliation Division of Pulmonary Medicine, University Hospitals of Geneva, Geneva, Switzerland

  ⨯
• Stephen S. Rich,

  Affiliation Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

  ⨯
• Bruce M. Psaty,

  Affiliations Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Departments of Medicine and Health Services, University of Washington, Seattle, United States of America, Group Health Research Institute, Group Health Cooperative, Seattle, Washington

  ⨯
• George T. O'Connor,

  Affiliations The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America, The Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

  ⨯
• Kari E. North,

  Affiliation Gillings School of Global Public Health, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

  ⨯
• Daniel B. Mirel,

  Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  ⨯
• Bernd Meibohm,

  Affiliation College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

  ⨯
• Lenore J. Launer,

  Affiliation National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Kay-Tee Khaw,

  Affiliation Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

  ⨯
• Anna-Liisa Hartikainen,

  Affiliation Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Oulu, Oulu, Finland

  ⨯
• Christopher J. Hammond,

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

  ⨯
• Sven Gläser,

  Affiliation Department of Internal Medicine B, University Hospital Greifswald, Greifswald, Germany

  ⨯
• Jonathan Marchini,

  Affiliation Department of Statistics, University of Oxford, United Kingdom

  ⨯
• Peter Kraft,

  Affiliation Departments of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Nicholas J. Wareham,

  Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom

  ⨯
• Henry Völzke,

  Affiliation Institute for Community Medicine, Study of Health In Pomerania (SHIP)/Clinical Epidemiological Research, University of Greifswald, Greifswald, Germany

  ⨯
• Bruno H. C. Stricker,

  Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Inspectorate of Healthcare, The Hague, The Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands

  ⨯
• Timothy D. Spector,

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

  ⨯
• Nicole M. Probst-Hensch,

  Affiliations Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

  ⨯
• Deborah Jarvis,

  Affiliations Respiratory Epidemiology and Public Health, Imperial College London, London, United Kingdom, MRC-HPA Centre for Environment and Health, Imperial College London, London, United Kingdom

  ⨯
• Marjo-Riitta Jarvelin,

  Affiliations Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom, MRC-HPA Centre for Environment and Health, Imperial College London, London, United Kingdom, Department of Children, Young People, and Families, National Institute for Health and Welfare, Oulu, Finland, Institute of Health Sciences, University of Oulu, Oulu, Finland, Biocenter Oulu, University of Oulu, Oulu, Finland

  ⨯
• Susan R. Heckbert,

  Affiliations Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Group Health Cooperative, Seattle, Washington

  ⨯
• Vilmundur Gudnason,

  Affiliations Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

  ⨯
• H. Marike Boezen,

  Affiliations GRIAC Research Institute, University Medical Center Groningen, Groningen, The Netherlands, Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, The LifeLines Cohort Study, Groningen, The Netherlands

  ⨯
• R. Graham Barr,

  Affiliations Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America

  ⨯
• Patricia A. Cassano ,

  ¶These authors were joint senior authors on this work.

  Affiliations Division of Nutritional Sciences, Cornell University, Ithaca, New York, United States of America, Department of Public Health, Weill Cornell Medical College, New York, New York, United States of America

  ⨯
• David P. Strachan ,

  ¶These authors were joint senior authors on this work.

  Affiliation Division of Population Health Sciences and Education, St. George's University of London, London, United Kingdom

  ⨯
• Myriam Fornage ,

  ¶These authors were joint senior authors on this work.

  Affiliations Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America, Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

  ⨯
• Ian P. Hall ,

  ¶These authors were joint senior authors on this work.

  Affiliation Division of Therapeutics and Molecular Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom

  ⨯
• Josée Dupuis ,

  ¶These authors were joint senior authors on this work.

  Affiliations The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Martin D. Tobin ,

  * E-mail: london2@niehs.nih.gov (S London); mt47@leicester.ac.uk (M Tobin)

  ¶These authors were joint senior authors on this work.

  Affiliation Departments of Health Sciences and Genetics, University of Leicester, Leicester, United Kingdom

  ⨯
•  [ ... ],
• Stephanie J. London

  * E-mail: london2@niehs.nih.gov (S London); mt47@leicester.ac.uk (M Tobin)

  ¶These authors were joint senior authors on this work.

  Affiliations Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America, Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America

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