Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations

Laura C. Greaves; Joanna L. Elson; Marco Nooteboom; John P. Grady; Geoffrey A. Taylor; Robert W. Taylor; John C. Mathers; Thomas B. L. Kirkwood; Doug M. Turnbull

doi:10.1371/journal.pgen.1003082

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Open Access

Peer-reviewed

Research Article

Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations

Laura C. Greaves ,

* E-mail: laura.greaves@ncl.ac.uk

Affiliations Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom, Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Joanna L. Elson,

Affiliation Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
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Marco Nooteboom,

Affiliation Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
John P. Grady,

Affiliation Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Geoffrey A. Taylor,

Affiliation Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Robert W. Taylor,

Affiliation Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
John C. Mathers,

Affiliations Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom, Human Nutrition Research Centre, Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle Upon Tyne, United Kingdom
⨯
Thomas B. L. Kirkwood,

Affiliations Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne, United Kingdom
⨯
Doug M. Turnbull

Affiliations Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom, Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯

Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations

Laura C. Greaves,
Joanna L. Elson,
Marco Nooteboom,
John P. Grady,
Geoffrey A. Taylor,
Robert W. Taylor,
John C. Mathers,
Thomas B. L. Kirkwood,
Doug M. Turnbull

Published: November 15, 2012
https://doi.org/10.1371/journal.pgen.1003082

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Mitochondrial DNA
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Point mutation
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Frameshift mutation
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Colon
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