Two Distinct Repressive Mechanisms for Histone 3 Lysine 4 Methylation through Promoting 3′-End Antisense Transcription

Thanasis Margaritis; Vincent Oreal; Nathalie Brabers; Laetitia Maestroni; Adeline Vitaliano-Prunier; Joris J. Benschop; Sander van Hooff; Dik van Leenen; Catherine Dargemont; Vincent Géli; Frank C. P. Holstege

doi:10.1371/journal.pgen.1002952

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Open Access

Peer-reviewed

Research Article

Two Distinct Repressive Mechanisms for Histone 3 Lysine 4 Methylation through Promoting 3′-End Antisense Transcription

Thanasis Margaritis,

Affiliation Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Vincent Oreal,

Affiliation Marseille Cancer Research Center (CRCM), U1068 Inserm, UMR7258 CNRS, Aix-Marseille Université, Institut Paoli-Calmettes, Marseille, France
⨯
Nathalie Brabers,

Affiliation Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Laetitia Maestroni,

Affiliation Marseille Cancer Research Center (CRCM), U1068 Inserm, UMR7258 CNRS, Aix-Marseille Université, Institut Paoli-Calmettes, Marseille, France
⨯
Adeline Vitaliano-Prunier,

Affiliation Institut Jacques Monod, Université Paris Diderot, CNRS, Paris, France
⨯
Joris J. Benschop,

Affiliation Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Sander van Hooff,

Affiliation Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Dik van Leenen,

Affiliation Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Catherine Dargemont ,

Contributed equally to this work with: Catherine Dargemont, Vincent Géli, Frank C. P. Holstege

* E-mail: dargemont.catherine@ijm.univ-paris-diderot.fr (CD); geli@ifr88.cnrs-mrs.fr (VG); f.c.p.holstege@umcutrecht.nl (FCPH)

Affiliation Institut Jacques Monod, Université Paris Diderot, CNRS, Paris, France
⨯
Vincent Géli ,

Contributed equally to this work with: Catherine Dargemont, Vincent Géli, Frank C. P. Holstege

* E-mail: dargemont.catherine@ijm.univ-paris-diderot.fr (CD); geli@ifr88.cnrs-mrs.fr (VG); f.c.p.holstege@umcutrecht.nl (FCPH)

Affiliation Marseille Cancer Research Center (CRCM), U1068 Inserm, UMR7258 CNRS, Aix-Marseille Université, Institut Paoli-Calmettes, Marseille, France
⨯
Frank C. P. Holstege

Contributed equally to this work with: Catherine Dargemont, Vincent Géli, Frank C. P. Holstege

* E-mail: dargemont.catherine@ijm.univ-paris-diderot.fr (CD); geli@ifr88.cnrs-mrs.fr (VG); f.c.p.holstege@umcutrecht.nl (FCPH)

Affiliation Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands
⨯

Two Distinct Repressive Mechanisms for Histone 3 Lysine 4 Methylation through Promoting 3′-End Antisense Transcription

Thanasis Margaritis,
Vincent Oreal,
Nathalie Brabers,
Laetitia Maestroni,
Adeline Vitaliano-Prunier,
Joris J. Benschop,
Sander van Hooff,
Dik van Leenen,
Catherine Dargemont,
Vincent Géli

Published: September 20, 2012
https://doi.org/10.1371/journal.pgen.1002952

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DNA transcription
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DNA methylation
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Histones
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Methylation
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Gene expression
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Saccharomyces cerevisiae
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Antisense RNA
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Nucleosomes
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