Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1

Kanae Iijima-Ando; Michiko Sekiya; Akiko Maruko-Otake; Yosuke Ohtake; Emiko Suzuki; Bingwei Lu; Koichi M. Iijima

doi:10.1371/journal.pgen.1002918

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Peer-reviewed

Research Article

Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1

Kanae Iijima-Ando ,

* E-mail: kanae.iijima-ando@jefferson.edu (KI-A); koichi.iijima@jefferson.edu (KMI)

Affiliation Laboratory of Neurogenetics and Pathobiology, Department of Neuroscience, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Michiko Sekiya,

Affiliation Laboratory of Neurobiology and Genetics, Department of Neuroscience, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Akiko Maruko-Otake ,

Contributed equally to this work with: Akiko Maruko-Otake, Yosuke Ohtake

Affiliations Laboratory of Neurogenetics and Pathobiology, Department of Neuroscience, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Laboratory of Neurobiology and Genetics, Department of Neuroscience, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Yosuke Ohtake ,

Contributed equally to this work with: Akiko Maruko-Otake, Yosuke Ohtake

Affiliation Laboratory of Neurogenetics and Pathobiology, Department of Neuroscience, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Emiko Suzuki,

Affiliations Gene Network Laboratory, National Institute of Genetics, Mishima, Shizuoka, Japan, Department of Genetics, SOKENDAI, Mishima, Shizuoka, Japan
⨯
Bingwei Lu,

Affiliation Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Koichi M. Iijima

* E-mail: kanae.iijima-ando@jefferson.edu (KI-A); koichi.iijima@jefferson.edu (KMI)

Affiliation Laboratory of Neurobiology and Genetics, Department of Neuroscience, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯

Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1

Kanae Iijima-Ando,
Michiko Sekiya,
Akiko Maruko-Otake,
Yosuke Ohtake,
Emiko Suzuki,
Bingwei Lu,
Koichi M. Iijima

Published: August 30, 2012
https://doi.org/10.1371/journal.pgen.1002918

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RNA interference
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Mitochondria
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