A Positive Feedback Loop Links Opposing Functions of P-TEFb/Cdk9 and Histone H2B Ubiquitylation to Regulate Transcript Elongation in Fission Yeast

• Miriam Sansó ,

  Contributed equally to this work with: Miriam Sansó, Karen M. Lee, Laia Viladevall

  Affiliation Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York, United States of America

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• Karen M. Lee ,

  Contributed equally to this work with: Miriam Sansó, Karen M. Lee, Laia Viladevall

  Affiliation Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York, United States of America

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• Laia Viladevall ,

  Contributed equally to this work with: Miriam Sansó, Karen M. Lee, Laia Viladevall

  Affiliation Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York, United States of America

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• Pierre-Étienne Jacques,

  Affiliation Institut de Recherches Cliniques de Montréal, Montréal, Canada

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• Viviane Pagé,

  Affiliation Department of Pharmacology and Therapeutics, McGill University, Montréal, Canada

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• Stephen Nagy,

  Affiliation Department of Pharmacology and Therapeutics, McGill University, Montréal, Canada

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• Ariane Racine,

  Affiliation Department of Pharmacology and Therapeutics, McGill University, Montréal, Canada

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• Courtney V. St. Amour,

  Affiliation Programs in Biochemistry, Cell and Molecular Biology, Weill Cornell Medical College, New York, New York, United States of America

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• Chao Zhang,

  Affiliation Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America

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• Kevan M. Shokat,

  Affiliation Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America

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• Beate Schwer,

  Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America

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• François Robert,

  Affiliation Institut de Recherches Cliniques de Montréal, Montréal, Canada

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• Robert P. Fisher ,

  * E-mail: robert.fisher@mssm.edu (RPF); jason.tanny@mcgill.ca (JCT)

  Affiliation Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York, United States of America

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• Jason C. Tanny

  * E-mail: robert.fisher@mssm.edu (RPF); jason.tanny@mcgill.ca (JCT)

  Affiliation Department of Pharmacology and Therapeutics, McGill University, Montréal, Canada

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