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Open Access
Peer-reviewed
Research Article
WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk
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Hou-Feng Zheng ,
Contributed equally to this work with: Hou-Feng Zheng, Jon H. Tobias, Emma Duncan, David M. Evans
Affiliations Department of Medicine, Human Genetics, McGill University, Montreal, Canada, Department of Epidemiology and Biostatistics, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada
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Jon H. Tobias ,
Contributed equally to this work with: Hou-Feng Zheng, Jon H. Tobias, Emma Duncan, David M. Evans
Affiliation Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
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Emma Duncan ,
Contributed equally to this work with: Hou-Feng Zheng, Jon H. Tobias, Emma Duncan, David M. Evans
Affiliations Human Genetics Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, University of Queensland, Brisbane, Australia, Endocrinology, Royal Brisbane and Women's Hospital, Brisbane, Australia
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David M. Evans ,
Contributed equally to this work with: Hou-Feng Zheng, Jon H. Tobias, Emma Duncan, David M. Evans
Affiliations Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
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Joel Eriksson,
Affiliation Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Lavinia Paternoster,
Affiliations Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
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Laura M. Yerges-Armstrong,
Affiliation Department of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
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Terho Lehtimäki,
Affiliation Department of Clinical Chemistry, Fimlab, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland
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Ulrica Bergström,
Affiliation Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden
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Mika Kähönen,
Affiliation Department of Clinical Physiology, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland
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Paul J. Leo,
Affiliation Human Genetics Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, University of Queensland, Brisbane, Australia
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Olli Raitakari,
Affiliation Research Centre of Applied and Preventive Cardiovascular Medicine and the Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland
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Marika Laaksonen,
Affiliation Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland
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Geoffrey C. Nicholson,
Affiliation Rural Clinical School, The University of Queensland, Toowoomba, Australia
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Jorma Viikari,
Affiliation Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland
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Martin Ladouceur,
Affiliation Montreal Heart Institute, Research Institute, Montreal, Canada
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Leo-Pekka Lyytikäinen,
Affiliation Department of Clinical Chemistry, Fimlab, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland
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Carolina Medina-Gomez,
Affiliations Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
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Fernando Rivadeneira,
Affiliations Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
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Richard L. Prince,
Affiliations Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Australia, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
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Harri Sievanen,
Affiliation Bone Research Group, UKK Institute, Tampere, Finland
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William D. Leslie,
Affiliation Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
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Dan Mellström,
Affiliation Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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John A. Eisman,
Affiliation Garvan Institute of Medical Research, University of New South Wales, Sydney, Australia
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Sofia Movérare-Skrtic,
Affiliation Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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David Goltzman,
Affiliation Department of Medicine, McGill University, Montreal, Canada
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David A. Hanley,
Affiliation Department of Medicine, University of Calgary, Calgary, Canada
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Graeme Jones,
Affiliation Menzies Research Institute, University of Tasmania, Hobart, Australia
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Beate St. Pourcain,
Affiliation School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
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Yongjun Xiao,
Affiliation Centre for Bone and Periodontal Research, McGill University, Montreal, Canada
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Nicholas J. Timpson,
Affiliations Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
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George Davey Smith,
Affiliations Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
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Ian R. Reid,
Affiliation Department of Medicine, University of Auckland, Auckland, New Zealand
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Susan M. Ring,
Affiliation School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
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Philip N. Sambrook,
Affiliation Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, Australia
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Magnus Karlsson,
Affiliation Clinical and Molecular Osteoporosis Research Unit, Department of Orthopaedics, Skane University Hospital, Lund University, Malmö, Sweden
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Elaine M. Dennison,
Affiliation Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom
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John P. Kemp,
Affiliations Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
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Patrick Danoy,
Affiliation Human Genetics Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, University of Queensland, Brisbane, Australia
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Adrian Sayers,
Affiliation Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
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Scott G. Wilson,
Affiliations Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Australia, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia, Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
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Maria Nethander,
Affiliation Genomics Core Facility, University of Gothenburg, Gothenburg, Sweden
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Eugene McCloskey,
Affiliations Academic Unit of Bone Metabolism, Metabolic Bone Centre, University of Sheffield, Sheffield, United Kingdom, NIHR Musculoskeletal Biomedical Research Unit, Sheffield Teaching Hospitals, Sheffield, United Kingdom
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Liesbeth Vandenput,
Affiliation Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Richard Eastell,
Affiliation Academic Unit of Bone Metabolism, Metabolic Bone Centre, University of Sheffield, Sheffield, United Kingdom
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Jeff Liu,
Affiliation Lexicon Pharmaceuticals, The Woodlands, Texas, United States of America
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Tim Spector,
Affiliation Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
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Braxton D. Mitchell,
Affiliation Department of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
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Elizabeth A. Streeten,
Affiliations Department of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Geriatric Research and Education Clinical Center (GRECC), Veterans Administration Medical Center, Baltimore, Maryland, United States of America
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Robert Brommage,
Affiliation Lexicon Pharmaceuticals, The Woodlands, Texas, United States of America
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Ulrika Pettersson-Kymmer,
Affiliations Department of Pharmacology and Neuroscience, Umeå University, Umeå, Sweden, Department of Public Health and Clinical Medicine, Umeå Unviersity, Umeå, Sweden
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Matthew A. Brown,
Affiliation Human Genetics Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, University of Queensland, Brisbane, Australia
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Claes Ohlsson ,
* E-mail: claes.ohlsson@medic.gu.se
¶These authors also contributed equally to this work.
Affiliation Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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J. Brent Richards ,
¶These authors also contributed equally to this work.
Affiliations Department of Medicine, Human Genetics, McGill University, Montreal, Canada, Department of Epidemiology and Biostatistics, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada, Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
⨯ - [ ... ],
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Mattias Lorentzon
¶These authors also contributed equally to this work.
Affiliation Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk
- Hou-Feng Zheng,
- Jon H. Tobias,
- Emma Duncan,
- David M. Evans,
- Joel Eriksson,
- Lavinia Paternoster,
- Laura M. Yerges-Armstrong,
- Terho Lehtimäki,
- Ulrica Bergström,
- Mika Kähönen
- Published: July 5, 2012
- https://doi.org/10.1371/journal.pgen.1002745