The App-Runx1 Region Is Critical for Birth Defects and Electrocardiographic Dysfunctions Observed in a Down Syndrome Mouse Model

Matthieu Raveau; Jacques M. Lignon; Valérie Nalesso; Arnaud Duchon; Yoram Groner; Andrew J. Sharp; Doulaye Dembele; Véronique Brault; Yann Hérault

doi:10.1371/journal.pgen.1002724

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Open Access

Peer-reviewed

Research Article

The App-Runx1 Region Is Critical for Birth Defects and Electrocardiographic Dysfunctions Observed in a Down Syndrome Mouse Model

Matthieu Raveau,

Affiliation Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Translational Medicine and Neurogenetics, CNRS, INSERM, Université de Strasbourg, UMR7104, UMR964, Illkirch, France
⨯
Jacques M. Lignon,

Affiliation Immunologie et Embryologie Moléculaire, CNRS Université d'Orléans, UMR6218, Orléans, France
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Valérie Nalesso,

Affiliation Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Translational Medicine and Neurogenetics, CNRS, INSERM, Université de Strasbourg, UMR7104, UMR964, Illkirch, France
⨯
Arnaud Duchon,

Affiliation Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Translational Medicine and Neurogenetics, CNRS, INSERM, Université de Strasbourg, UMR7104, UMR964, Illkirch, France
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Yoram Groner,

Affiliation Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
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Andrew J. Sharp,

Affiliation Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
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Doulaye Dembele,

Affiliation Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Translational Medicine and Neurogenetics, CNRS, INSERM, Université de Strasbourg, UMR7104, UMR964, Illkirch, France
⨯
Véronique Brault,

Affiliation Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Translational Medicine and Neurogenetics, CNRS, INSERM, Université de Strasbourg, UMR7104, UMR964, Illkirch, France
⨯
Yann Hérault

* E-mail: herault@igbmc.fr

Affiliations Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Translational Medicine and Neurogenetics, CNRS, INSERM, Université de Strasbourg, UMR7104, UMR964, Illkirch, France, Transgénèse et Archivage d'Animaux Modèles, CNRS, UPS44, Orléans, France, Institut Clinique de la Souris, Illkirch, France
⨯

The App-Runx1 Region Is Critical for Birth Defects and Electrocardiographic Dysfunctions Observed in a Down Syndrome Mouse Model

Matthieu Raveau,
Jacques M. Lignon,
Valérie Nalesso,
Arnaud Duchon,
Yoram Groner,
Andrew J. Sharp,
Doulaye Dembele,
Véronique Brault,
Yann Hérault

Published: May 31, 2012
https://doi.org/10.1371/journal.pgen.1002724

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