Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome

Jian Li; R. Alan Harris; Sau Wai Cheung; Cristian Coarfa; Mira Jeong; Margaret A. Goodell; Lisa D. White; Ankita Patel; Sung-Hae Kang; Chad Shaw; A. Craig Chinault; Tomasz Gambin; Anna Gambin; James R. Lupski; Aleksandar Milosavljevic

doi:10.1371/journal.pgen.1002692

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Open Access

Peer-reviewed

Research Article

Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome

Jian Li,

Affiliations Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
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R. Alan Harris,

Affiliations Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Sau Wai Cheung,

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Cristian Coarfa,

Affiliations Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
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Mira Jeong,

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Margaret A. Goodell,

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Lisa D. White,

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Ankita Patel,

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Sung-Hae Kang,

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Chad Shaw,

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
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A. Craig Chinault,

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
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Tomasz Gambin,

Affiliation Institute of Computer Science, Warsaw University of Technology, Warsaw, Poland
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Anna Gambin,

Affiliation Institute of Informatics, Warsaw University, Warsaw, Poland
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James R. Lupski,

Affiliations Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America, Texas Children's Hospital, Houston, Texas, United States of America
⨯
Aleksandar Milosavljevic

* E-mail: amilosav@bcm.edu

Affiliations Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
⨯

Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome

Jian Li,
R. Alan Harris,
Sau Wai Cheung,
Cristian Coarfa,
Mira Jeong,
Margaret A. Goodell,
Lisa D. White,
Ankita Patel,
Sung-Hae Kang,
Chad Shaw

Published: May 17, 2012
https://doi.org/10.1371/journal.pgen.1002692

Reader Comments (7)

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07 Dec 2015
01:43 GMT
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association independently validated Posted by amilosav on 07 Dec 2015 at 01:43 GMT
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03 Mar 2013
05:38 GMT
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Additional commentary on this article Posted by asharp on 28 Feb 2013 at 22:32 GMT
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01 Mar 2013
03:42 GMT
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Technical concerns about this article have been addressed by the authors Posted by amilosav on 01 Mar 2013 at 03:42 GMT
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01 Mar 2013
03:14 GMT
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Notice of technical comment on this article Posted by asharp on 28 Feb 2013 at 22:28 GMT

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