Physiological Notch Signaling Maintains Bone Homeostasis via RBPjk and Hey Upstream of NFATc1

Xiaolin Tu; Jianquan Chen; Joohyun Lim; Courtney M. Karner; Seung-Yon Lee; Julia Heisig; Cornelia Wiese; Kameswaran Surendran; Raphael Kopan; Manfred Gessler; Fanxin Long

doi:10.1371/journal.pgen.1002577

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Peer-reviewed

Research Article

Physiological Notch Signaling Maintains Bone Homeostasis via RBPjk and Hey Upstream of NFATc1

Xiaolin Tu,

Current address: Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Affiliation Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Jianquan Chen,

Affiliation Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Joohyun Lim,

Affiliation Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Courtney M. Karner,

Affiliation Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Seung-Yon Lee,

Affiliation Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Julia Heisig,

Affiliation Developmental Biochemistry, Biocentre, University of Wuerzburg, Wuerzburg, Germany
⨯
Cornelia Wiese,

Affiliation Developmental Biochemistry, Biocentre, University of Wuerzburg, Wuerzburg, Germany
⨯
Kameswaran Surendran,

Affiliation Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Raphael Kopan,

Affiliation Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Manfred Gessler,

Affiliation Developmental Biochemistry, Biocentre, University of Wuerzburg, Wuerzburg, Germany
⨯
Fanxin Long

* E-mail: flong@wustl.edu

Affiliations Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯

Physiological Notch Signaling Maintains Bone Homeostasis via RBPjk and Hey Upstream of NFATc1

Xiaolin Tu,
Jianquan Chen,
Joohyun Lim,
Courtney M. Karner,
Seung-Yon Lee,
Julia Heisig,
Cornelia Wiese,
Kameswaran Surendran,
Raphael Kopan,
Manfred Gessler

Published: March 22, 2012
https://doi.org/10.1371/journal.pgen.1002577

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Osteoblasts
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