Nos2 Inactivation Promotes the Development of Medulloblastoma in Ptch1+/− Mice by Deregulation of Gap43–Dependent Granule Cell Precursor Migration

Daniel Haag; Petra Zipper; Viola Westrich; Daniela Karra; Karin Pfleger; Grischa Toedt; Frederik Blond; Nicolas Delhomme; Meinhard Hahn; Julia Reifenberger; Guido Reifenberger; Peter Lichter

doi:10.1371/journal.pgen.1002572

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Open Access

Peer-reviewed

Research Article

Nos2 Inactivation Promotes the Development of Medulloblastoma in Ptch1^+/− Mice by Deregulation of Gap43–Dependent Granule Cell Precursor Migration

Daniel Haag ,

Contributed equally to this work with: Daniel Haag, Petra Zipper

Affiliation Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Petra Zipper ,

Contributed equally to this work with: Daniel Haag, Petra Zipper

Affiliation Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany
⨯
Viola Westrich,

Affiliation Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany
⨯
Daniela Karra,

Affiliation Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany
⨯
Karin Pfleger,

Affiliation Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Grischa Toedt,

Affiliation Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Frederik Blond,

Affiliation Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Nicolas Delhomme,

Affiliation Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Meinhard Hahn,

Affiliation Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Julia Reifenberger,

Affiliation Department of Dermatology, Heinrich Heine University, Düsseldorf, Germany
⨯
Guido Reifenberger ,

¶These authors were joint senior authors on this work.

Affiliation Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany
⨯
Peter Lichter

* E-mail: Peter.Lichter@dkfz.de

Affiliation Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯

Nos2 Inactivation Promotes the Development of Medulloblastoma in Ptch1^+/− Mice by Deregulation of Gap43–Dependent Granule Cell Precursor Migration

Daniel Haag,
Petra Zipper,
Viola Westrich,
Daniela Karra,
Karin Pfleger,
Grischa Toedt,
Frederik Blond,
Nicolas Delhomme,
Meinhard Hahn,
Julia Reifenberger

Published: March 15, 2012
https://doi.org/10.1371/journal.pgen.1002572

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