The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution

Esmé Waanders; Blanca Scheijen; Laurens T. van der Meer; Simon V. van Reijmersdal; Liesbeth van Emst; Yvet Kroeze; Edwin Sonneveld; Peter M. Hoogerbrugge; Ad Geurts van Kessel; Frank N. van Leeuwen; Roland P. Kuiper

doi:10.1371/journal.pgen.1002533

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Peer-reviewed

Research Article

The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution

Esmé Waanders ,

Contributed equally to this work with: Esmé Waanders, Blanca Scheijen

Affiliation Department of Human Genetics, Radboud University Nijmegen Medical Centre, Radboud University Centre of Oncology and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯
Blanca Scheijen ,

Contributed equally to this work with: Esmé Waanders, Blanca Scheijen

Affiliation Pediatric Oncology, Radboud University Nijmegen Medical Centre, Radboud University Centre of Oncology and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯
Laurens T. van der Meer,

Affiliation Pediatric Oncology, Radboud University Nijmegen Medical Centre, Radboud University Centre of Oncology and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯
Simon V. van Reijmersdal,

Affiliation Department of Human Genetics, Radboud University Nijmegen Medical Centre, Radboud University Centre of Oncology and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯
Liesbeth van Emst,

Affiliation Pediatric Oncology, Radboud University Nijmegen Medical Centre, Radboud University Centre of Oncology and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯
Yvet Kroeze,

Affiliation Department of Human Genetics, Radboud University Nijmegen Medical Centre, Radboud University Centre of Oncology and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯
Edwin Sonneveld,

Affiliation Dutch Childhood Oncology Group (DCOG), The Hague, The Netherlands
⨯
Peter M. Hoogerbrugge,

Affiliations Pediatric Oncology, Radboud University Nijmegen Medical Centre, Radboud University Centre of Oncology and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands, Dutch Childhood Oncology Group (DCOG), The Hague, The Netherlands
⨯
Ad Geurts van Kessel,

Affiliation Department of Human Genetics, Radboud University Nijmegen Medical Centre, Radboud University Centre of Oncology and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯
Frank N. van Leeuwen,

Affiliation Pediatric Oncology, Radboud University Nijmegen Medical Centre, Radboud University Centre of Oncology and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯
Roland P. Kuiper

* E-mail: R.Kuiper@antrg.umcn.nl

Affiliation Department of Human Genetics, Radboud University Nijmegen Medical Centre, Radboud University Centre of Oncology and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯

The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution

Esmé Waanders,
Blanca Scheijen,
Laurens T. van der Meer,
Simon V. van Reijmersdal,
Liesbeth van Emst,
Yvet Kroeze,
Edwin Sonneveld,
Peter M. Hoogerbrugge,
Ad Geurts van Kessel,
Frank N. van Leeuwen

Published: February 16, 2012
https://doi.org/10.1371/journal.pgen.1002533

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