GTPase Activity and Neuronal Toxicity of Parkinson's Disease–Associated LRRK2 Is Regulated by ArfGAP1

Open Access

Peer-reviewed

Research Article

Klodjan Stafa ,

Contributed equally to this work with: Klodjan Stafa, Alzbeta Trancikova

Affiliation Laboratory of Molecular Neurodegenerative Research, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
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Alzbeta Trancikova ,

Contributed equally to this work with: Klodjan Stafa, Alzbeta Trancikova

Affiliation Laboratory of Molecular Neurodegenerative Research, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
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Philip J. Webber,

Affiliation Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
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Liliane Glauser,

Affiliation Laboratory of Molecular Neurodegenerative Research, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
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Andrew B. West,

Affiliation Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
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Darren J. Moore

* E-mail: darren.moore@epfl.ch

Affiliation Laboratory of Molecular Neurodegenerative Research, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
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Neurons
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Neurites
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Guanosine triphosphatase
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Golgi apparatus
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GTP hydrolysis
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Immunoprecipitation
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Axons
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Toxicity
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