Reduction of NADPH-Oxidase Activity Ameliorates the Cardiovascular Phenotype in a Mouse Model of Williams-Beuren Syndrome

Victoria Campuzano; Maria Segura-Puimedon; Verena Terrado; Carolina Sánchez-Rodríguez; Mathilde Coustets; Mauricio Menacho-Márquez; Julián Nevado; Xosé R. Bustelo; Uta Francke; Luis A. Pérez-Jurado

doi:10.1371/journal.pgen.1002458

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Open Access

Peer-reviewed

Research Article

Reduction of NADPH-Oxidase Activity Ameliorates the Cardiovascular Phenotype in a Mouse Model of Williams-Beuren Syndrome

Victoria Campuzano ,

* E-mail: victoria.campuzano@upf.edu

Affiliations Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain
⨯
Maria Segura-Puimedon,

Affiliations Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain
⨯
Verena Terrado,

Affiliations Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain
⨯
Carolina Sánchez-Rodríguez,

Affiliation Unidad de Investigación, Hospital Universitario de Getafe, Getafe, Spain
⨯
Mathilde Coustets,

Affiliation Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
⨯
Mauricio Menacho-Márquez,

Affiliation Centro de Investigación del Cáncer e Instituto de Biología Molecular del Cáncer de Salamanca (IMBCC), CSIC–Universidad de Salamanca, Salamanca, Spain
⨯
Julián Nevado,

Affiliations Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain, INGEMM-Instituto de Genética Médica y Molecular/IdiPAZ, Madrid, Spain
⨯
Xosé R. Bustelo,

Affiliation Centro de Investigación del Cáncer e Instituto de Biología Molecular del Cáncer de Salamanca (IMBCC), CSIC–Universidad de Salamanca, Salamanca, Spain
⨯
Uta Francke,

Affiliation Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Luis A. Pérez-Jurado

Affiliations Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain
⨯

Reduction of NADPH-Oxidase Activity Ameliorates the Cardiovascular Phenotype in a Mouse Model of Williams-Beuren Syndrome

Victoria Campuzano,
Maria Segura-Puimedon,
Verena Terrado,
Carolina Sánchez-Rodríguez,
Mathilde Coustets,
Mauricio Menacho-Márquez,
Julián Nevado,
Xosé R. Bustelo,
Uta Francke,
Luis A. Pérez-Jurado

Published: February 2, 2012
https://doi.org/10.1371/journal.pgen.1002458

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