Plasticity of BRCA2 Function in Homologous Recombination: Genetic Interactions of the PALB2 and DNA Binding Domains

Nicolas Siaud; Maria A. Barbera; Akinori Egashira; Isabel Lam; Nicole Christ; Katharina Schlacher; Bing Xia; Maria Jasin

doi:10.1371/journal.pgen.1002409

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Peer-reviewed

Research Article

Plasticity of BRCA2 Function in Homologous Recombination: Genetic Interactions of the PALB2 and DNA Binding Domains

Nicolas Siaud,

Current address: Institut de Biologie des Plantes, Bâtiment 630, CNRS UMR 8618, Université Paris 11 Sud, Orsay, France

Affiliation Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Maria A. Barbera ,

Contributed equally to this work with: Maria A. Barbera, Akinori Egashira

Affiliation Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Akinori Egashira ,

Contributed equally to this work with: Maria A. Barbera, Akinori Egashira

Current address: Department of Surgery and Science, Graduate School of Kyushu University, Fukuoka, Japan

Affiliation Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Isabel Lam,

Affiliations Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Louis V. Gerstner Sloan-Kettering Graduate School of Biomedical Sciences, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Nicole Christ,

Current address: MedImmune, Cambridge, United Kingdom

Affiliation Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Katharina Schlacher,

Affiliation Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Bing Xia,

Affiliation Department of Radiation Oncology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, United States of America
⨯
Maria Jasin

* E-mail: m-jasin@ski.mskcc.org

Affiliations Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Louis V. Gerstner Sloan-Kettering Graduate School of Biomedical Sciences, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯

Plasticity of BRCA2 Function in Homologous Recombination: Genetic Interactions of the PALB2 and DNA Binding Domains

Nicolas Siaud,
Maria A. Barbera,
Akinori Egashira,
Isabel Lam,
Nicole Christ,
Katharina Schlacher,
Bing Xia,
Maria Jasin

Published: December 15, 2011
https://doi.org/10.1371/journal.pgen.1002409

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DNA-binding proteins
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Point mutation
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Protein domains
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Recombinase polymerase amplification
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Cell fusion
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DNA repair
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