Charcot-Marie-Tooth–Linked Mutant GARS Is Toxic to Peripheral Neurons Independent of Wild-Type GARS Levels

William W. Motley; Kevin L. Seburn; Mir Hussain Nawaz; Kathy E. Miers; Jun Cheng; Anthony Antonellis; Eric D. Green; Kevin Talbot; Xiang-Lei Yang; Kenneth H. Fischbeck; Robert W. Burgess

doi:10.1371/journal.pgen.1002399

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Peer-reviewed

Research Article

Charcot-Marie-Tooth–Linked Mutant GARS Is Toxic to Peripheral Neurons Independent of Wild-Type GARS Levels

William W. Motley,

Affiliations The Jackson Laboratory, Bar Harbor, Maine, United States of America, Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America, MRC Functional Genomics Unit, University of Oxford, Oxford, United Kingdom
⨯
Kevin L. Seburn,

Affiliation The Jackson Laboratory, Bar Harbor, Maine, United States of America
⨯
Mir Hussain Nawaz,

Affiliation The Scripps Research Institute, La Jolla, California, United States of America
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Kathy E. Miers,

Affiliation The Jackson Laboratory, Bar Harbor, Maine, United States of America
⨯
Jun Cheng,

Affiliation Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
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Anthony Antonellis,

Affiliations Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America, Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
⨯
Eric D. Green,

Affiliation Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Kevin Talbot,

Affiliations MRC Functional Genomics Unit, University of Oxford, Oxford, United Kingdom, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
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Xiang-Lei Yang,

Affiliation The Scripps Research Institute, La Jolla, California, United States of America
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Kenneth H. Fischbeck,

Affiliation Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
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Robert W. Burgess

* E-mail: robert.burgess@jax.org

Affiliation The Jackson Laboratory, Bar Harbor, Maine, United States of America
⨯

Charcot-Marie-Tooth–Linked Mutant GARS Is Toxic to Peripheral Neurons Independent of Wild-Type GARS Levels

William W. Motley,
Kevin L. Seburn,
Mir Hussain Nawaz,
Kathy E. Miers,
Jun Cheng,
Anthony Antonellis,
Eric D. Green,
Kevin Talbot,
Xiang-Lei Yang,
Kenneth H. Fischbeck

Published: December 1, 2011
https://doi.org/10.1371/journal.pgen.1002399

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