A Novel Protein LZTFL1 Regulates Ciliary Trafficking of the BBSome and Smoothened

Seongjin Seo; Qihong Zhang; Kevin Bugge; David K. Breslow; Charles C. Searby; Maxence V. Nachury; Val C. Sheffield

doi:10.1371/journal.pgen.1002358

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Peer-reviewed

Research Article

A Novel Protein LZTFL1 Regulates Ciliary Trafficking of the BBSome and Smoothened

Seongjin Seo,

Current address: Department of Ophthalmology and Visual Sciences, University of Iowa College of Medicine, Iowa City, Iowa, United States of America

Affiliations Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
⨯
Qihong Zhang,

Affiliations Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
⨯
Kevin Bugge,

Affiliations Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
⨯
David K. Breslow,

Affiliation Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Charles C. Searby,

Affiliations Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
⨯
Maxence V. Nachury,

Affiliation Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Val C. Sheffield

* E-mail: val-sheffield@uiowa.edu

Affiliations Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
⨯

A Novel Protein LZTFL1 Regulates Ciliary Trafficking of the BBSome and Smoothened

Seongjin Seo,
Qihong Zhang,
Kevin Bugge,
David K. Breslow,
Charles C. Searby,
Maxence V. Nachury,
Val C. Sheffield

Published: November 3, 2011
https://doi.org/10.1371/journal.pgen.1002358

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Cilia
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Protein transport
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Small interfering RNA
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Transfection
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Genetically modified animals
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Hedgehog signaling
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Membrane trafficking
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