Positional Cloning of a Type 2 Diabetes Quantitative Trait Locus; Tomosyn-2, a Negative Regulator of Insulin Secretion

Sushant Bhatnagar; Angie T. Oler; Mary E. Rabaglia; Donald S. Stapleton; Kathryn L. Schueler; Nathan A. Truchan; Sara L. Worzella; Jonathan P. Stoehr; Susanne M. Clee; Brian S. Yandell; Mark P. Keller; Debbie C. Thurmond; Alan D. Attie

doi:10.1371/journal.pgen.1002323

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Open Access

Peer-reviewed

Research Article

Positional Cloning of a Type 2 Diabetes Quantitative Trait Locus; Tomosyn-2, a Negative Regulator of Insulin Secretion

Sushant Bhatnagar ,

Contributed equally to this work with: Sushant Bhatnagar, Angie T. Oler

Affiliation Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Angie T. Oler ,

Contributed equally to this work with: Sushant Bhatnagar, Angie T. Oler

Affiliation Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Mary E. Rabaglia,

Affiliation Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Donald S. Stapleton,

Affiliation Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Kathryn L. Schueler,

Affiliation Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Nathan A. Truchan,

Affiliation Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Sara L. Worzella,

Affiliation Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Jonathan P. Stoehr,

Affiliation Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Susanne M. Clee,

Affiliation Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada
⨯
Brian S. Yandell,

Affiliation Department of Statistics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Mark P. Keller,

Affiliation Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Debbie C. Thurmond,

Affiliation Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Alan D. Attie

* E-mail: adattie@wisc.edu

Affiliation Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯

Positional Cloning of a Type 2 Diabetes Quantitative Trait Locus; Tomosyn-2, a Negative Regulator of Insulin Secretion

Sushant Bhatnagar,
Angie T. Oler,
Mary E. Rabaglia,
Donald S. Stapleton,
Kathryn L. Schueler,
Nathan A. Truchan,
Sara L. Worzella,
Jonathan P. Stoehr,
Susanne M. Clee,
Brian S. Yandell

Published: October 6, 2011
https://doi.org/10.1371/journal.pgen.1002323

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Insulin secretion
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Glucose
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Insulin
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Single nucleotide polymorphisms
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Genetic loci
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Diabetes mellitus
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Type 2 diabetes
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