Cell Type–Specific Transcriptome Analysis Reveals a Major Role for Zeb1 and miR-200b in Mouse Inner Ear Morphogenesis

Ronna Hertzano; Ran Elkon; Kiyoto Kurima; Annie Morrisson; Siaw-Lin Chan; Michelle Sallin; Andrew Biedlingmaier; Douglas S. Darling; Andrew J. Griffith; David J. Eisenman; Scott E. Strome

doi:10.1371/journal.pgen.1002309

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Open Access

Peer-reviewed

Research Article

Cell Type–Specific Transcriptome Analysis Reveals a Major Role for Zeb1 and miR-200b in Mouse Inner Ear Morphogenesis

Ronna Hertzano ,

* E-mail: rhertzano@smail.umaryland.edu

Affiliation Department of Otorhinolaryngology–Head and Neck Surgery, University of Maryland, Baltimore, Maryland, United States of America
⨯
Ran Elkon,

Affiliation Division of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, The Netherlands
⨯
Kiyoto Kurima,

Affiliation Molecular Biology and Genetics Section, Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Annie Morrisson,

Affiliation Department of Otorhinolaryngology–Head and Neck Surgery, University of Maryland, Baltimore, Maryland, United States of America
⨯
Siaw-Lin Chan,

Affiliation Department of Otorhinolaryngology–Head and Neck Surgery, University of Maryland, Baltimore, Maryland, United States of America
⨯
Michelle Sallin,

Affiliation Department of Otorhinolaryngology–Head and Neck Surgery, University of Maryland, Baltimore, Maryland, United States of America
⨯
Andrew Biedlingmaier,

Affiliation Department of Otorhinolaryngology–Head and Neck Surgery, University of Maryland, Baltimore, Maryland, United States of America
⨯
Douglas S. Darling,

Affiliation Department of Oral Health and Rehabilitation and Center for Genetics and Molecular Medicine, University of Louisville, Louisville, Kentucky, United States of America
⨯
Andrew J. Griffith,

Affiliation Molecular Biology and Genetics Section, Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland, United States of America
⨯
David J. Eisenman,

Affiliation Department of Otorhinolaryngology–Head and Neck Surgery, University of Maryland, Baltimore, Maryland, United States of America
⨯
Scott E. Strome

Affiliation Department of Otorhinolaryngology–Head and Neck Surgery, University of Maryland, Baltimore, Maryland, United States of America
⨯

Cell Type–Specific Transcriptome Analysis Reveals a Major Role for Zeb1 and miR-200b in Mouse Inner Ear Morphogenesis

Ronna Hertzano,
Ran Elkon,
Kiyoto Kurima,
Annie Morrisson,
Siaw-Lin Chan,
Michelle Sallin,
Andrew Biedlingmaier,
Douglas S. Darling,
Andrew J. Griffith,
David J. Eisenman

Published: September 29, 2011
https://doi.org/10.1371/journal.pgen.1002309

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Inner ear
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Sensory perception
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Gene expression
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Deafness
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Epithelial cells
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MicroRNAs
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Marker genes
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Transcriptome analysis
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