Study of FoxA Pioneer Factor at Silent Genes Reveals Rfx-Repressed Enhancer at Cdx2 and a Potential Indicator of Esophageal Adenocarcinoma Development

Jason A. Watts; Chaolin Zhang; Andres J. Klein-Szanto; Jay D. Kormish; Jian Fu; Michael Q. Zhang; Kenneth S. Zaret

doi:10.1371/journal.pgen.1002277

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Peer-reviewed

Research Article

Study of FoxA Pioneer Factor at Silent Genes Reveals Rfx-Repressed Enhancer at Cdx2 and a Potential Indicator of Esophageal Adenocarcinoma Development

Jason A. Watts,

Affiliations Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Cancer Biology Program and Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
⨯
Chaolin Zhang,

Affiliation Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
⨯
Andres J. Klein-Szanto,

Affiliation Cancer Biology Program and Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
⨯
Jay D. Kormish,

Affiliation Cancer Biology Program and Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
⨯
Jian Fu,

Affiliation Cancer Biology Program and Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
⨯
Michael Q. Zhang,

Affiliations Department of Molecular and Cell Biology, Center for Systems Biology, The University of Texas at Dallas, Richardson, Texas, United States of America, Ministry of Education Key Laboratory of Bioinformatics and Bioinformatics Division, Tsinghua National Laboratory for Information Science and Technology, Tsinghua University, Beijing, China
⨯
Kenneth S. Zaret

* E-mail: zaret@fccc.edu

Affiliations Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Cancer Biology Program and Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
⨯

Study of FoxA Pioneer Factor at Silent Genes Reveals Rfx-Repressed Enhancer at Cdx2 and a Potential Indicator of Esophageal Adenocarcinoma Development

Jason A. Watts,
Chaolin Zhang,
Andres J. Klein-Szanto,
Jay D. Kormish,
Jian Fu,
Michael Q. Zhang,
Kenneth S. Zaret

Published: September 15, 2011
https://doi.org/10.1371/journal.pgen.1002277

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