Drosophila IAP1-Mediated Ubiquitylation Controls Activation of the Initiator Caspase DRONC Independent of Protein Degradation

Tom V. Lee; Yun Fan; Shiuan Wang; Mayank Srivastava; Meike Broemer; Pascal Meier; Andreas Bergmann

doi:10.1371/journal.pgen.1002261

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Research Article

Drosophila IAP1-Mediated Ubiquitylation Controls Activation of the Initiator Caspase DRONC Independent of Protein Degradation

Tom V. Lee ,

Contributed equally to this work with: Tom V. Lee, Yun Fan

Affiliation Department of Biochemistry and Molecular Biology, Genes and Development Graduate Program, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Yun Fan ,

Contributed equally to this work with: Tom V. Lee, Yun Fan

Affiliation Department of Biochemistry and Molecular Biology, Genes and Development Graduate Program, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Shiuan Wang,

Affiliations Department of Biochemistry and Molecular Biology, Genes and Development Graduate Program, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Graduate Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Mayank Srivastava,

Affiliation Department of Biochemistry and Molecular Biology, Genes and Development Graduate Program, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Meike Broemer,

Affiliation The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, United Kingdom
⨯
Pascal Meier,

Affiliation The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, United Kingdom
⨯
Andreas Bergmann

* E-mail: andreas.bergmann@umassmed.edu

Affiliations Department of Biochemistry and Molecular Biology, Genes and Development Graduate Program, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Graduate Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯

Drosophila IAP1-Mediated Ubiquitylation Controls Activation of the Initiator Caspase DRONC Independent of Protein Degradation

Tom V. Lee,
Yun Fan,
Shiuan Wang,
Mayank Srivastava,
Meike Broemer,
Pascal Meier,
Andreas Bergmann

Published: September 1, 2011
https://doi.org/10.1371/journal.pgen.1002261

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