Fine Mapping of Five Loci Associated with Low-Density Lipoprotein Cholesterol Detects Variants That Double the Explained Heritability

• Serena Sanna ,

  Contributed equally to this work with: Serena Sanna, Bingshan Li, Antonella Mulas

  * E-mail: goncalo@umich.edu (GRA); serena.sanna@inn.cnr.it (SS)

  Affiliation Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

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• Bingshan Li ,

  Contributed equally to this work with: Serena Sanna, Bingshan Li, Antonella Mulas

  Affiliation Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Antonella Mulas ,

  Contributed equally to this work with: Serena Sanna, Bingshan Li, Antonella Mulas

  Affiliation Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

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• Carlo Sidore,

  Affiliations Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy, Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America, Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy

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• Hyun M. Kang,

  Affiliation Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Anne U. Jackson,

  Affiliation Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Maria Grazia Piras,

  Affiliation Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

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• Gianluca Usala,

  Affiliation Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

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• Giuseppe Maninchedda,

  Affiliation Shardna Life Sciences, Pula, Italy

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• Alessandro Sassu,

  Affiliation Shardna Life Sciences, Pula, Italy

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• Fabrizio Serra,

  Affiliation Shardna Life Sciences, Pula, Italy

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• Maria Antonietta Palmas,

  Affiliation Shardna Life Sciences, Pula, Italy

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• William H. Wood III,

  Affiliation Gene Expression and Genomics Unit, Research Resources Branch, National Institute on Aging, Baltimore, Maryland, United States of America

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• Inger Njølstad,

  Affiliation Department of Community Medicine, Faculty of Health Sciences, University of Tromso, Tromso, Norway

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• Markku Laakso,

  Affiliation Department of Medicine, University of Eastern Finland, Kuopio, Finland

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• Kristian Hveem,

  Affiliation Department of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway

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• Jaakko Tuomilehto,

  Affiliations Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland, Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland, South Ostrobothnia Central Hospital, Seinajoki, Finland

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• Timo A. Lakka,

  Affiliations Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio, Finland, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland

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• Rainer Rauramaa,

  Affiliation Kuopio Research Institute of Exercise Medicine, Kuopio, Finland

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• Michael Boehnke,

  Affiliation Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Francesco Cucca,

  Affiliations Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy, Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy

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• Manuela Uda,

  Affiliation Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

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• David Schlessinger ,

  ¶These authors also contributed equally to this work.

  Affiliation Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, United States of America

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• Ramaiah Nagaraja ,

  ¶These authors also contributed equally to this work.

  Affiliation Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, United States of America

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•  [ ... ],
• Gonçalo R. Abecasis

  * E-mail: goncalo@umich.edu (GRA); serena.sanna@inn.cnr.it (SS)

  ¶These authors also contributed equally to this work.

  Affiliation Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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