Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy

• Olga Gorlova ,

  Contributed equally to this work with: Olga Gorlova, Jose-Ezequiel Martin, Blanca Rueda, Bobby P. C. Koeleman, Spanish Scleroderma Group

  * E-mail: oygorlov@mdanderson.org (O Gorlova); martin@ipb.csic.es (J Martin)

  Affiliation Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas, United States of America

  ⨯
• Jose-Ezequiel Martin ,

  Contributed equally to this work with: Olga Gorlova, Jose-Ezequiel Martin, Blanca Rueda, Bobby P. C. Koeleman, Spanish Scleroderma Group

  Affiliation Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain

  ⨯
• Blanca Rueda ,

  Contributed equally to this work with: Olga Gorlova, Jose-Ezequiel Martin, Blanca Rueda, Bobby P. C. Koeleman, Spanish Scleroderma Group

  Affiliation Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain

  ⨯
• Bobby P. C. Koeleman ,

  Contributed equally to this work with: Olga Gorlova, Jose-Ezequiel Martin, Blanca Rueda, Bobby P. C. Koeleman, Spanish Scleroderma Group

  Affiliation Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands

  ⨯
• Jun Ying,

  Affiliation Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas, United States of America

  ⨯
• Maria Teruel,

  Affiliation Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain

  ⨯
• Lina-Marcela Diaz-Gallo,

  Affiliation Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain

  ⨯
• Jasper C. Broen,

  Affiliation Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

  ⨯
• Madelon C. Vonk,

  Affiliation Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

  ⨯
• Carmen P. Simeon,

  Affiliation Servicio de Medicina Interna, Hospital Valle de Hebron, Barcelona, Spain

  ⨯
• Behrooz Z. Alizadeh,

  Affiliation University Medical Centre Groningen, Department of Epidemiology, Groningen, The Netherlands

  ⨯
• Marieke J. H. Coenen,

  Affiliation Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

  ⨯
• Alexandre E. Voskuyl,

  Affiliation VU University Medical Center, Amsterdam, The Netherlands

  ⨯
• Annemie J. Schuerwegh,

  Affiliation Department of Rheumatology, University of Leiden, Leiden, The Netherlands

  ⨯
• Piet L. C. M. van Riel,

  Affiliation Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

  ⨯
• Marie Vanthuyne,

  Affiliation Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium

  ⨯
• Ruben van 't Slot,

  Affiliation Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands

  ⨯
• Annet Italiaander,

  Affiliation Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands

  ⨯
• Roel A. Ophoff,

  Affiliation Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands

  ⨯
• Nicolas Hunzelmann,

  Affiliation Department of Dermatology, University of Cologne, Cologne, Germany

  ⨯
• Vicente Fonollosa,

  Affiliation Servicio de Medicina Interna, Hospital Valle de Hebron, Barcelona, Spain

  ⨯
• Norberto Ortego-Centeno,

  Affiliation Servicio de Medicina Interna, Hospital Clínico Universitario, Granada, Spain

  ⨯
• Miguel A. González-Gay,

  Affiliation Servicio de Reumatología, Hospital Marqués de Valdecilla, Santander, Spain

  ⨯
• Francisco J. García-Hernández,

  Affiliation Servicio de Medicina Interna, Hospital Virgen del Rocio, Sevilla, Spain

  ⨯
• María F. González-Escribano,

  Affiliation Servicio de Inmunología, Hospital Virgen del Rocío, Sevilla, Spain

  ⨯
• Paolo Airo,

  Affiliation Rheumatology Unit and Chair, Spedali Civili, Università degli Studi, Brescia, Italy

  ⨯
• Jacob van Laar,

  Affiliation Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom

  ⨯
• Jane Worthington,

  Affiliation Department of Rheumatology and Epidemiology, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom

  ⨯
• Roger Hesselstrand,

  Affiliation Department of Clinical Sciences, Division of Rheumatology, Lund University, Lund, Sweden

  ⨯
• Vanessa Smith,

  Affiliation Ghent University, Ghent, Belgium

  ⨯
• Filip de Keyser,

  Affiliation Ghent University, Ghent, Belgium

  ⨯
• Fredric Houssiau,

  Affiliation Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium

  ⨯
• Meng May Chee,

  Affiliation Centre for Rheumatic Diseases, Glasgow Royal Infirmary Glasgow, United Kingdom

  ⨯
• Rajan Madhok,

  Affiliation Centre for Rheumatic Diseases, Glasgow Royal Infirmary Glasgow, United Kingdom

  ⨯
• Paul G. Shiels,

  Affiliation Department of Surgery, Western Infirmary Glasgow, University of Glasgow, Glasgow, United Kingdom

  ⨯
• Rene Westhovens,

  Affiliation Katholieke Universiteit Leuven, Leuven, Belgium

  ⨯
• Alexander Kreuter,

  Affiliation Department of Dermatology, Josefs-Hospital, Ruhr University Bochum, Germany

  ⨯
• Elfride de Baere,

  Affiliation Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium

  ⨯
• Torsten Witte,

  Affiliation Hannover Medical School, Hannover, Germany

  ⨯
• Leonid Padyukov,

  Affiliation Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden

  ⨯
• Annika Nordin,

  Affiliation Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden

  ⨯
• Raffaella Scorza,

  Affiliation Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and University of Milan, Milan, Italy

  ⨯
• Claudio Lunardi,

  Affiliation Department of Medicine, Policlinico GB Rossi, University of Verona, Italy

  ⨯
• Benedicte A. Lie,

  Affiliation Institute of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway

  ⨯
• Anna-Maria Hoffmann-Vold,

  Affiliation Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway

  ⨯
• Øyvind Palm,

  Affiliation Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway

  ⨯
• Paloma García de la Peña,

  Affiliation Servicio de Reumatología, Hospital Ramón y Cajal, Madrid, Spain

  ⨯
• Patricia Carreira,

  Affiliation Hospital 12 de Octubre, Madrid, Spain

  ⨯
• Spanish Scleroderma Group ,

  Contributed equally to this work with: Olga Gorlova, Jose-Ezequiel Martin, Blanca Rueda, Bobby P. C. Koeleman, Spanish Scleroderma Group

  Affiliation For membership of the Spanish Scleroderma Group, please see Text S1.

  ⨯
• John Varga,

  Affiliation Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

  ⨯
• Monique Hinchcliff,

  Affiliation Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

  ⨯
• Annette T. Lee,

  Affiliation Feinstein Institute of Medical Research, Manhasset, New York, United States of America

  ⨯
• Pravitt Gourh,

  Affiliation The University of Texas Health Science Center–Houston, Houston, Texas, United States of America

  ⨯
• Christopher I. Amos,

  Affiliation Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas, United States of America

  ⨯
• Frederick M. Wigley,

  Affiliation The Johns Hopkins University Medical Center, Baltimore, Maryland, United States of America

  ⨯
• Laura K. Hummers,

  Affiliation Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  ⨯
• J. Hummers,

  Affiliation The Johns Hopkins University Medical Center, Baltimore, Maryland, United States of America

  ⨯
• J. Lee Nelson,

  Affiliation Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  ⨯
• Gabriella Riemekasten,

  Affiliation Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany

  ⨯
• Ariane Herrick,

  Affiliation Department of Rheumatology and Epidemiology, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom

  ⨯
• Lorenzo Beretta,

  Affiliation Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and University of Milan, Milan, Italy

  ⨯
• Carmen Fonseca,

  Affiliation Centre for Rheumatology, Royal Free and University College School, London, United Kingdom

  ⨯
• Christopher P. Denton,

  Affiliation Centre for Rheumatology, Royal Free and University College School, London, United Kingdom

  ⨯
• Peter K. Gregersen,

  Affiliation Feinstein Institute of Medical Research, Manhasset, New York, United States of America

  ⨯
• Sandeep Agarwal,

  Affiliation The University of Texas Health Science Center–Houston, Houston, Texas, United States of America

  ⨯
• Shervin Assassi,

  Affiliation The University of Texas Health Science Center–Houston, Houston, Texas, United States of America

  ⨯
• Filemon K. Tan,

  Affiliation The University of Texas Health Science Center–Houston, Houston, Texas, United States of America

  ⨯
• Frank C. Arnett ,

  ¶These authors also contributed equally to this work.

  Affiliation The University of Texas Health Science Center–Houston, Houston, Texas, United States of America

  ⨯
• Timothy R. D. J. Radstake ,

  ¶These authors also contributed equally to this work.

  Affiliation Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

  ⨯
• Maureen D. Mayes ,

  ¶These authors also contributed equally to this work.

  Affiliation The University of Texas Health Science Center–Houston, Houston, Texas, United States of America

  ⨯
•  [ ... ],
• Javier Martin

  * E-mail: oygorlov@mdanderson.org (O Gorlova); martin@ipb.csic.es (J Martin)

  ¶These authors also contributed equally to this work.

  Affiliation Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain

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